Amphotericin B (AmB), a broad-spectrum polyene antibiotic in the clinic for more than fifty
years, remains the gold standard in the treatment of life-threatening invasive fungal …

Undeniably, new antifungal treatments are necessary against pathogenic fungi. Fungal
infections have significantly increased in recent decades, being highlighted as important …

Background The goal of therapeutic drug monitoring (TDM) is to determine the appropriate
exposure of difficult-to-manage medications to optimize the clinical outcomes in patients in …

Despite improvements in treatment and diagnostics over the last two decades, invasive
aspergillosis (IA) remains a devastating fungal disease. The number of …

Amphotericin B has long been crucial for treating many serious infectious diseases, such as
invasive fungal infections and visceral leishmaniasis, particularly for patients who are …

In the 1980s, the center of entrepreneurial activity for the application of liposome science to
medicine took the form of a company called Vestar Inc.(which became NeXstar …

Drug-induced nephrotoxicity is responsible for 20% to 60% of cases of acute kidney injury in
hospitalized patients and is associated with increased morbidity and mortality in both …

The purpose of this review is to describe antifungal therapeutic candidates in preclinical and
clinical development derived from, or directly influenced by, the immune system, with a …

Introduction Invasive fungal infections continue to be important causes of morbidity and
mortality in severely ill and immunocompromised patient populations. The past three …

Invasive fungal infections are an important cause of morbidity and mortality, especially in
critically ill patients. Increasing resistance rates and inadequate antifungal exposure have …