Mitochondrial protein transport: Versatility of translocases and mechanisms

JD Busch, LF Fielden, N Pfanner, N Wiedemann - Molecular Cell, 2023 - cell.com
Biogenesis of mitochondria requires the import of approximately 1,000 different precursor
proteins into and across the mitochondrial membranes. Mitochondria exhibit a wide variety …

Role of the TOM complex in protein import into mitochondria: structural views

Y Araiso, K Imai, T Endo - Annual Review of Biochemistry, 2022 - annualreviews.org
Mitochondria are central to energy production, metabolism and signaling, and apoptosis. To
make new mitochondria from preexisting mitochondria, the cell needs to import …

The mitochondrial outer membrane protein Tom70-mediator in protein traffic, membrane contact sites and innate immunity

S Kreimendahl, J Rassow - International journal of molecular sciences, 2020 - mdpi.com
Tom70 is a versatile adaptor protein of 70 kDa anchored in the outer membrane of
mitochondria in metazoa, fungi and amoeba. The tertiary structure was resolved for the …

Coupling of import and assembly pathways in mitochondrial protein biogenesis

A Grevel, N Pfanner, T Becker - Biological chemistry, 2019 - degruyter.com
Biogenesis and function of mitochondria depend on the import of about 1000 precursor
proteins that are produced on cytosolic ribosomes. The translocase of the outer membrane …

Versatility of preprotein transfer from the cytosol to mitochondria

T Becker, J Song, N Pfanner - Trends in cell biology, 2019 - cell.com
Mitochondrial biogenesis requires the import of a large number of precursor proteins from
the cytosol. Although specific membrane-bound preprotein translocases have been …

Evolution of mitochondrial protein import–lessons from trypanosomes

A Schneider - Biological chemistry, 2020 - degruyter.com
The evolution of mitochondrial protein import and the systems that mediate it marks the
boundary between the endosymbiotic ancestor of mitochondria and a true organelle that is …

Down the membrane hole: Ion channels in protozoan parasites

V Jimenez, S Mesones - PLoS pathogens, 2022 - journals.plos.org
Parasitic diseases caused by protozoans are highly prevalent around the world,
disproportionally affecting developing countries, where coinfection with other …

Anaerobic peroxisomes in Entamoeba histolytica metabolize myo-inositol

Z Verner, V Žárský, T Le, RK Narayanasamy… - PLoS …, 2021 - journals.plos.org
Entamoeba histolytica is believed to be devoid of peroxisomes, like most anaerobic protists.
In this work, we provided the first evidence that peroxisomes are present in E. histolytica …

The hydrogenosome of Trichomonas vaginalis

J Tachezy, A Makki, I Hrdý - Journal of Eukaryotic Microbiology, 2022 - Wiley Online Library
This review is dedicated to the 50th anniversary of the discovery of hydrogenosomes by
Miklós Müller and Donald Lindmark, which we will celebrate the following year. It was a long …

Reduced mitochondria provide an essential function for the cytosolic methionine cycle

J Zítek, Z Füssy, SC Treitli, P Peña-Diaz, Z Vaitová… - Current Biology, 2022 - cell.com
The loss of mitochondria in oxymonad protists has been associated with the redirection of
the essential Fe-S cluster assembly to the cytosol. Yet as our knowledge of diverse free …