Farnesoid X receptor (FXR) is a ligand-activated transcription factor involved in the control of
bile acid (BA) synthesis and enterohepatic circulation. FXR can influence glucose and lipid …

Colorectal cancer (CRC) is a predominant malignancy worldwide, being the fourth most
common cause of mortality and morbidity. The CRC incidence in adolescents, young adults …

Background and Aims Dietary fat intake is associated with increased risk of colorectal
cancer (CRC). We examined the role of high-fat diet (HFD) in driving CRC through …

The intestinal epithelium withstands continuous mechanical, chemical and biological insults
despite its single-layered, simple epithelial structure. The crypt–villus tissue architecture in …

This document updates the colorectal cancer (CRC) screening recommendations of the US
Multi-Society Task Force of Colorectal Cancer (MSTF), which represents the American …

Importance Colorectal cancer (CRC) incidence and mortality among individuals younger
than 50 years (early-onset CRC) are increasing. The reasons for such increases are largely …

In contrast to the decreasing incidence of colorectal cancer (CRC) in older populations, the
incidence has nearly doubled in younger adults since the early 1990s. Approximately 1 in …

The strongest nonmodifiable risk factors for CRC and precancerous polyps are age, male
sex, and family history of CRC. Current evidence indicates that smoking, obesity, and diet …

Background The causative factors for the recent increase in early-onset colorectal cancer
(EO-CRC) incidence are unknown. We sought to determine if early-onset disease is …

Altered metabolism of lipids is currently considered a hallmark characteristic of many
malignancies, including colorectal cancer (CRC). Lipids are a large group of metabolites …