The Kelch-like ECH-associated protein 1-NF-E2-related factor 2 (KEAP1-NRF2) system
forms the major node of cellular and organismal defense against oxidative and electrophilic …

Exposure to antioxidants and xenobiotics triggers the expression of a myriad of genes
encoding antioxidant proteins, detoxifying enzymes, and xenobiotic transporters to offer …

The small Maf proteins (sMafs) are basic region leucine zipper (bZIP)-type transcription
factors. The basic region of the Maf family is unique among the bZIP factors, and it …

Fos and Jun family proteins regulate the expression of a myriad of genes in a variety of
tissues and cell types. This functional versatility emerges from their interactions with related …

MafA is a transcription factor that binds to the promoter in the insulin gene and has been
postulated to regulate insulin transcription in response to serum glucose levels, but there is …

Recent progress in the analysis of transcriptional regulation has revealed the presence of an
exquisite functional network comprising the Maf and Cap'n'collar (CNC) families of …

Abstract Jun: Fos and Jun: ATF complexes represent two classes of AP-1 dimers that (1)
preferentially bind to either heptameric or octameric AP-1 binding sites, and (2) are …

Of the three critical enhancer elements that mediate β-cell-specific and glucose-responsive
expression of the insulin gene, only the identity of the transcription factor binding to the …

The insulin gene is specifically expressed in β-cells of the Langerhans islets of the
pancreas, and its transcription is regulated by the circulating glucose level. Previous reports …

Abstract The C1/RIPE3b1 (− 118/− 107 bp) binding factor regulates pancreatic-β-cell-
specific and glucose-regulated transcription of the insulin gene. In the present study, the …