miRNAs and NAFLD: from pathophysiology to therapy
M Gjorgjieva, C Sobolewski, D Dolicka, MC de Sousa… - Gut, 2019 - gut.bmj.com
Non-alcoholic fatty liver disease (NAFLD) is associated with a thorough reprogramming of
hepatic metabolism. Epigenetic mechanisms, in particular those associated with …
hepatic metabolism. Epigenetic mechanisms, in particular those associated with …
miRNAs in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis
CH Liu, J Ampuero, A Gil-Gómez, R Montero-Vallejo… - Journal of …, 2018 - Elsevier
Background & Aims microRNAs (miRNAs) are deregulated in non-alcoholic fatty liver
disease (NAFLD) and have been proposed as useful markers for the diagnosis and …
disease (NAFLD) and have been proposed as useful markers for the diagnosis and …
The epigenetic drug discovery landscape for metabolic-associated fatty liver disease
Despite decades of research, effective therapies for metabolic (dysfunction)-associated fatty
liver disease (MAFLD) are lacking. An increasing body of evidence suggests that epigenetic …
liver disease (MAFLD) are lacking. An increasing body of evidence suggests that epigenetic …
[HTML][HTML] The emerging role of microRNAs in NAFLD: highlight of microRNA-29a in modulating oxidative stress, inflammation, and beyond
Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease and
ranges from steatosis to steatohepatitis and to liver fibrosis. Lipotoxicity in hepatocytes …
ranges from steatosis to steatohepatitis and to liver fibrosis. Lipotoxicity in hepatocytes …
[HTML][HTML] The role of PKM2 in metabolic reprogramming: insights into the regulatory roles of non-coding RNAs
DL Puckett, M Alquraishi, W Chowanadisai… - International Journal of …, 2021 - mdpi.com
Pyruvate kinase is a key regulator in glycolysis through the conversion of
phosphoenolpyruvate (PEP) into pyruvate. Pyruvate kinase exists in various isoforms that …
phosphoenolpyruvate (PEP) into pyruvate. Pyruvate kinase exists in various isoforms that …
[HTML][HTML] Circulating microRNAs 34a, 122, and 192 are linked to obesity-associated inflammation and metabolic disease in pediatric patients
J Lischka, A Schanzer, A Hojreh… - International Journal of …, 2021 - nature.com
Background Obesity-associated chronic low-grade inflammation leads to dysregulation of
central lipid and glucose metabolism pathways leading to metabolic disorders. MicroRNAs …
central lipid and glucose metabolism pathways leading to metabolic disorders. MicroRNAs …
[HTML][HTML] Non-invasive prediction of NAFLD severity: a comprehensive, independent validation of previously postulated serum microRNA biomarkers
M López-Riera, I Conde, G Quintas, L Pedrola… - Scientific reports, 2018 - nature.com
Liver biopsy is currently the only reliable method to establish nonalcoholic fatty liver disease
(NAFLD) severity. However, this technique is invasive and occasionally associated with …
(NAFLD) severity. However, this technique is invasive and occasionally associated with …
NAFLD and vitamin D: Evidence for intersection of microRNA-regulated pathways
Non-alcoholic fatty liver disease (NAFLD) is now the most common cause of chronic liver
disease, worldwide. The molecular pathogenesis of NAFLD is complex, involving numerous …
disease, worldwide. The molecular pathogenesis of NAFLD is complex, involving numerous …
A new insight into the roles of MiRNAs in metabolic syndrome
Y Huang, Y Yan, W Xv, G Qian, C Li… - BioMed research …, 2018 - Wiley Online Library
Metabolic syndrome (MetS), which includes several clinical components such as abdominal
obesity, insulin resistance (IR), dyslipidemia, microalbuminuria, hypertension …
obesity, insulin resistance (IR), dyslipidemia, microalbuminuria, hypertension …
NAFLD as a continuous driver in the whole spectrum of vascular disease
Vascular disease is the prime determinant to cardiovascular morbidities and mortalities,
which comprises the early vascular damage and subsequent cardiovascular events. Non …
which comprises the early vascular damage and subsequent cardiovascular events. Non …