Congestion is a cardinal sign of heart failure (HF). In the past, it was seen as a
homogeneous epiphenomenon that identified patients with advanced HF. However, current …

Endothelial progenitor cells (EPCs) are currently being studied as candidate cell sources for
revascularization strategies. Despite these promising results, widespread clinical …

Pulmonary arterial hypertension (PAH) is a vascular remodeling disease of cardiopulmonary
units. No cure is currently available due to an incomplete understanding of vascular …

Congestion plays a major role in the pathogenesis, presentation, and prognosis of heart
failure and is an important therapeutic target. However, its severity and organ and …

Radiotherapy is an indispensable modality in comprehensive treatment of breast cancer.
However, inherent or acquired radiation resistance of tumors compromises the efficacy of …

Inflammation primarily influences the initiation, progression, and deterioration of many
human diseases, and immune cells are the principal forces that modulate the balance of …

Myocardial protection against ischemia/reperfusion injury (IRI) is mediated by various
ligands, activating different cellular signaling cascades. These include classical cytosolic …

Cancer development is a multistep process that may be induced by a variety of compounds.
Environmental substances, such as pesticides, have been associated with different human …

Background The intestinal microbiota fundamentally guides the development of a normal
intestinal physiology, the education, and functioning of the mucosal immune system. The …

The netrins form a family of laminin-related proteins which were first described as
modulators of cell migration and axonal guidance during fetal development. Netrin-1 is the …