CA1 pyramidal cell diversity enabling parallel information processing in the hippocampus

I Soltesz, A Losonczy - Nature neuroscience, 2018 - nature.com
Hippocampal network operations supporting spatial navigation and declarative memory are
traditionally interpreted in a framework where each hippocampal area, such as the dentate …

Heterogeneity within classical cell types is the rule: lessons from hippocampal pyramidal neurons

MS Cembrowski, N Spruston - Nature Reviews Neuroscience, 2019 - nature.com
The mechanistic operation of brain regions is often interpreted by partitioning constituent
neurons into 'cell types'. Historically, such cell types were broadly defined by their …

Architecture of the mouse brain synaptome

F Zhu, M Cizeron, Z Qiu, R Benavides-Piccione… - Neuron, 2018 - cell.com
Synapses are found in vast numbers in the brain and contain complex proteomes. We
developed genetic labeling and imaging methods to examine synaptic proteins in individual …

[HTML][HTML] Sublayer-specific coding dynamics during spatial navigation and learning in hippocampal area CA1

NB Danielson, JD Zaremba, P Kaifosh, J Bowler… - Neuron, 2016 - cell.com
The mammalian hippocampus is critical for spatial information processing and episodic
memory. Its primary output cells, CA1 pyramidal cells (CA1 PCs), vary in genetics …

Spatial gene-expression gradients underlie prominent heterogeneity of CA1 pyramidal neurons

MS Cembrowski, JL Bachman, L Wang, K Sugino… - Neuron, 2016 - cell.com
Tissue and organ function has been conventionally understood in terms of the interactions
among discrete and homogeneous cell types. This approach has proven difficult in …

Dissociable structural and functional hippocampal outputs via distinct subiculum cell classes

MS Cembrowski, MG Phillips, SF DiLisio, BC Shields… - Cell, 2018 - cell.com
The mammalian hippocampus, comprised of serially connected subfields, participates in
diverse behavioral and cognitive functions. It has been postulated that parallel circuitry …

Differential structure of hippocampal CA1 pyramidal neurons in the human and mouse

R Benavides-Piccione, M Regalado-Reyes… - Cerebral …, 2020 - academic.oup.com
Pyramidal neurons are the most common cell type and are considered the main output
neuron in most mammalian forebrain structures. In terms of function, differences in the …

Deep brain stimulation for Alzheimer's disease: stimulation parameters and potential mechanisms of action

Y Luo, Y Sun, X Tian, X Zheng, X Wang, W Li… - Frontiers in aging …, 2021 - frontiersin.org
Deep brain stimulation (DBS) is a neurosurgical technique that regulates neuron activity by
using internal pulse generators to electrodes in specific target areas of the brain. As a blind …

Teneurin-3 controls topographic circuit assembly in the hippocampus

DS Berns, LA DeNardo, DT Pederick, L Luo - Nature, 2018 - nature.com
Brain functions rely on specific patterns of connectivity. Teneurins are evolutionarily
conserved transmembrane proteins that instruct synaptic partner matching in Drosophila …

Direct cortical inputs to hippocampal area CA1 transmit complementary signals for goal-directed navigation

JC Bowler, A Losonczy - Neuron, 2023 - cell.com
The subregions of the entorhinal cortex (EC) are conventionally thought to compute
dichotomous representations for spatial processing, with the medial EC (MEC) providing a …