Improved understanding of the oxygen-dependent regulation of erythropoiesis has provided
new insights into the pathogenesis of anaemia associated with renal failure and has led to …

The hormone erythropoietin (Epo) maintains red blood cell mass by promoting the survival,
proliferation and differentiation of erythrocytic progenitors. Circulating Epo originates mainly …

In the light of the enthusiasm regarding the use of recombinant human erythropoietin (Epo)
and its analogues for treatment of the anaemias of chronic renal failure and malignancies it …

BACKGROUND AND OBJECTIVES: The human health impact of the historic and current
mining and processing of non-ferrous metals in the African Copperbelt is not known. This …

1 History 1 2 The atmosphere 16 3 Geography and the human response to altitude 28 4
Genetics and high altitude 40 5 Altitude acclimatization and deterioration 53 6 Control of …

Populations residing for millennia on the high-altitude plateaus of the world started natural
experiments that we can evaluate to address questions about the processes of evolution …

Human exposure biomonitoring in the African Copperbelt (Katanga, southern DR Congo)
revealed elevated cobalt (Co) exposure in the general population. This study was designed …

The generation of reactive oxygen species is typically associated with hyperoxia and
ischemia reperfusion. Recent evidence has suggested that increased oxidative stress may …

Background. The prevalence of chronic kidney disease (CKD) at high altitude is not known.
We conducted a population-based survey in Tibet to identify the prevalence and associated …

All metazoan organisms are committed to respiration, using oxygen as the terminal electron
acceptor in a reaction that is carried out by cytochrome c oxidase. The consequence is that …