Pharmacokinetic/pharmacodynamic (PK/PD) analysis has proved to be very useful to
establish rational dosage regimens of antimicrobial agents in human and veterinary …

Antibiotics as antibacterial drugs have saved many lives, but have also become a victim of
their own success. Their widespread abuse reduces their anti-infective effectiveness and …

Background Critically ill patients undergo extensive physiological alterations that will have
impact on antibiotic pharmacokinetics. Up to 60% of intensive care unit (ICU) patients meet …

Background Therapeutic drug monitoring (TDM) for antibiotic drugs represents a
consolidated practice to optimize the effectiveness and to limit the toxicity of specific drugs …

Background and objective External evaluation is an important issue in the population
pharmacokinetic analysis of antibiotics. The purpose of this review was to summarize the …

Therapeutic drug monitoring (TDM) of antibiotics has been practiced for more than half a
century, but it is still not widely applied for infected patients. It has a traditional focus on …

Objectives Despite therapeutic vancomycin is regularly monitored, its dose requirements
vary considerably between individuals. Various innovative vancomycin dosing strategies …

Background: Pharmacokinetic nomograms, equations, and software are considered the
main tools available for Therapeutic Drug Monitoring (TDM). Model-informed precision …

Background and Objective. Clozapine is a second‐generation antipsychotic drug that is
considered the most effective treatment for refractory schizophrenia. Several clozapine …

Aim Risperidone is the most commonly prescribed antipsychotic drug to children and
adolescents worldwide, but it is associated with serious side effects, including weight gain …