G protein-gated inwardly rectifying potassium channels (Kir3/GirK) are important for
maintaining resting membrane potential, cell excitability and inhibitory neurotransmission …

G protein-gated inwardly rectifying K+ (GIRK/Kir3) channels exert a critical inhibitory
influence on neurons. Neuronal GIRK channels mediate the G protein-dependent …

Inward rectifying potassium (Kir) channels play important roles in both excitable and
nonexcitable cells of various organ systems and could represent valuable new drug targets …

Synonymous and noncoding single nucleotide polymorphisms (SNPs) in the KCNJ6 gene,
encoding G protein-gated inwardly rectifying potassium channel subunit 2 (GIRK2), have …

How G protein-coupled receptors (GPCRs) evoke specific biological outcomes while
utilizing a limited array of G proteins and effectors is poorly understood, particularly in native …

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
amyloid plaques and cognitive decline, the latter of which is thought to be driven by soluble …

Genome-wide association studies (GWAS) of electroencephalographic endophenotypes for
alcohol use disorder (AUD) has identified noncoding polymorphisms within the KCNJ6 …

Social adversity not only causes severe psychological diseases but also may improve
people's ability to learn and grow. However, the beneficial effects of social adversity are …

G-protein-gated inwardly rectifying potassium (GIRK) channels are critical determinants of
neuronal excitability. They have been proposed as potential targets to restore …

The most distinctive feature of Down syndrome (DS) is moderate to severe cognitive
impairment. Genetic, molecular, and neuronal mechanisms of this complex DS phenotype …