Myocardial ischemia is a disease with high morbidity and mortality, for which reperfusion is
currently the standard intervention. However, the reperfusion may lead to further myocardial …

Autophagy is a cytoplasmic degradation system, which is important for starvation adaptation
and cellular quality control. Recent advances in understanding autophagy highlight its …

Macroautophagy is an intracellular degradation system that utilizes the autophagosome to
deliver cytoplasmic components to the lysosome. Measuring autophagic activity is critically …

Background: Increased fatty acid oxidation (FAO) has long been considered a culprit in the
development of obesity/diabetes mellitus–induced cardiomyopathy. However, enhancing …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Autophagy is a lysosome-dependent intracellular degradation system required for various
physiological processes and can be dysregulated in human disease. To understand its …

Background—Mitochondrial autophagy is an important mediator of mitochondrial quality
control in cardiomyocytes. The occurrence of mitochondrial autophagy and its significance …

Rationale: Both fusion and fission contribute to mitochondrial quality control. How
unopposed fusion affects survival of cardiomyocytes and left ventricular function in the heart …

Rationale: The rennin-angiotensin-aldosterone system (RAAS) plays a critical role in the
pathogenesis of diabetic cardiomyopathy, but the role of a member of RAAS, angiotensin IV …

Cell death is a fundamental process in cardiac pathologies. Recent studies have revealed
multiple forms of cell death, and several of them have been demonstrated to underlie …