Epigenetics is the epi-information beyond the DNA sequence that can be inherited from
parents to offspring. From years of studies, people have found that histone modifications …

Macromolecular assemblies that regulate chromatin structure using the energy of ATP
hydrolysis have critical roles in development, cancer, and stem cell biology. The ATPases of …

Aberrant DNA replication is a major source of the mutations and chromosome
rearrangements that are associated with pathological disorders. When replication is …

Stability and function of eukaryotic genomes are closely linked to chromatin structure and
organization. During cell division the entire genome must be accurately replicated and the …

The integrity of the genome is constantly challenged by intrinsic and extrinsic genotoxic
stresses that damage DNA. The cellular responses to DNA damage are orchestrated by …

In recent years, an increasing number of studies have shown that prokaryotes and
eukaryotes are armed with sophisticated mechanisms to restart stalled or collapsed …

The maintenance of genome integrity is essential for organism survival and for the
inheritance of traits to offspring. Genomic instability is caused by DNA damage, aberrant …

ATP-dependent chromatin remodellers modulate nucleosome dynamics by mobilizing or
disassembling nucleosomes, as well as altering nucleosome composition. These chromatin …

The integrity of DNA is continuously challenged by metabolism-derived and environmental
genotoxic agents that cause a variety of DNA lesions, including base alterations and breaks …

Little is known about how cells ensure DNA replication in the face of RNA polymerase II
(RNAPII)-mediated transcription, especially under conditions of replicative stress. Here we …