The past 10 years have seen great advances in our ability to manipulate cell fate, including
the induction of pluripotency in vitro to generate induced pluripotent stem cells (iPSCs). This …

A major cause for vision impairment and blindness in industrialized countries is the loss of
the light-sensing retinal tissue in the eye. Photoreceptor damage is one of the main …

The immunomodulatory properties of mesenchymal stem cells (MSCs) make them attractive
therapeutic agents for a wide range of diseases. However, the highly demanding cell doses …

This study explores the use of human embryonic stem cells (hESCs) for assessing
nanotoxicology, specifically, the effect of gold nanoparticles (AuNPs) of different core sizes …

Abstract Long interspersed element-1 (LINE-1 or L1) retrotransposons account for nearly
17% of human genomic DNA and represent a major evolutionary force that has reshaped …

Exposure to lead (Pb) during childhood can result in learning disabilities and behavioral
problems. Although described in animal models, whether Pb exposure also alters neuronal …

Recent technological advances in the generation, characterization, and bioprocessing of
human pluripotent stem cells (hPSCs) have created new hope for their use as a source for …

For more than thirty years, the dog has been used as a model for human diseases. Despite
efforts made to develop canine embryonic stem cells, success has been elusive. Here, we …

Background Sox2 is a well-established pluripotent transcription factor that plays an essential
role in establishing and maintaining pluripotent stem cells (PSCs). It is also thought to be a …

Human induced pluripotent stem cells (hiPSCs) were generated on several biomaterials
from human amniotic fluid in completely xeno-free and feeder-free conditions via the …