Sperm DNA fragmentation testing: Summary evidence and clinical practice recommendations
We herein summarise the evidence concerning the impact of sperm DNA fragmentation in
various clinical infertility scenarios and the advances on sperm DNA fragmentation tests …
various clinical infertility scenarios and the advances on sperm DNA fragmentation tests …
[HTML][HTML] Sex and gender differences in developmental programming of metabolism
Background The early life environment experienced by an individual in utero and during the
neonatal period is a major factor in shaping later life disease risk-including susceptibility to …
neonatal period is a major factor in shaping later life disease risk-including susceptibility to …
Intracytoplasmic sperm injection for male infertility and consequences for offspring
Intracytoplasmic sperm injection (ICSI) has become the most commonly used method of
fertilization in assisted reproductive technology. The primary reasons for its popularity stem …
fertilization in assisted reproductive technology. The primary reasons for its popularity stem …
Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of …
T Fullston, EMCO Teague, NO Palmer… - The FASEB …, 2013 - Wiley Online Library
Obesity is highly prevalent, and its incidence is increasing. The previous study showing a
major effect of paternal obesity on metabolic health of offspring is confounded by …
major effect of paternal obesity on metabolic health of offspring is confounded by …
Understanding transgenerational epigenetic inheritance via the gametes in mammals
L Daxinger, E Whitelaw - Nature Reviews Genetics, 2012 - nature.com
It is known that information that is not contained in the DNA sequence—epigenetic
information—can be inherited from the parent to the offspring. However, many questions …
information—can be inherited from the parent to the offspring. However, many questions …
Sperm-borne miRNAs and endo-siRNAs are important for fertilization and preimplantation embryonic development
Although it is believed that mammalian sperm carry small noncoding RNAs (sncRNAs) into
oocytes during fertilization, it remains unknown whether these sperm-borne sncRNAs truly …
oocytes during fertilization, it remains unknown whether these sperm-borne sncRNAs truly …
The presence, role and clinical use of spermatozoal RNAs
M Jodar, S Selvaraju, E Sendler… - Human reproduction …, 2013 - academic.oup.com
BACKGROUND Spermatozoa are highly differentiated, transcriptionally inert cells
characterized by a compact nucleus with minimal cytoplasm. Nevertheless they contain a …
characterized by a compact nucleus with minimal cytoplasm. Nevertheless they contain a …
Sperm-borne microRNA-34c is required for the first cleavage division in mouse
In mammals, the sperm deliver mRNA of unknown function into the oocytes during
fertilization. The role of sperm microRNAs (miRNAs) in preimplantation development is …
fertilization. The role of sperm microRNAs (miRNAs) in preimplantation development is …
Protamines and male infertility
R Oliva - Human reproduction update, 2006 - academic.oup.com
Protamines are the major nuclear sperm proteins. The human sperm nucleus contains two
types of protamine: protamine 1 (P1) encoded by a single-copy gene and the family of …
types of protamine: protamine 1 (P1) encoded by a single-copy gene and the family of …
Sperm selection in natural conception: what can we learn from Mother Nature to improve assisted reproduction outcomes?
BACKGROUND In natural conception only a few sperm cells reach the ampulla or the site of
fertilization. This population is a selected group of cells since only motile cells can pass …
fertilization. This population is a selected group of cells since only motile cells can pass …