The exclusive expression of uromodulin in the kidneys has made it an intriguing protein in
kidney and cardiovascular research. Genome-wide association studies discovered variants …

Uromodulin (also known as Tamm–Horsfall protein) is a kidney-specific glycoprotein
secreted bidirectionally into urine and into the circulation, and it is the most abundant protein …

Estimated glomerular filtration rate (eGFR) impacts the concentration of plasma biomarkers
confounding biomarker association studies of eGFR with reverse causation. To identify …

Identifying circulating proteins associated with cognitive function may point to biomarkers
and molecular process of cognitive impairment. Few studies have investigated the …

The identification of genetic factors associated with the risk, onset, and progression of kidney
disease has the potential to provide mechanistic insights and therapeutic perspectives. In …

The kidney medulla is a specialized region with important homeostatic functions. It has been
implicated in genetic and developmental disorders along with ischemic and drug-induced …

Uromodulin (or Tamm-Horsfall protein) is a glycoprotein uniquely produced in the kidney by
tubular cells of the thick ascending limb of the loop of Henle and early distal tubules. This …

Uromodulin, also known as Tamm-Horsfall protein, represents the predominant urinary
protein in healthy individuals. Over the years, studies have revealed compelling …

Abstract The structure Siaα2, 3 (GalNAcβ1, 4) Gal-is the epitope of the Sda antigen, which is
expressed on the erythrocytes and secretions of the vast majority of Caucasians, carried by …

Anti-Sda is naturally occurring and reacts well at room temperature and to a lesser extent at
37 C. The antibodies are of immunoglobulin M (IgM) type, although IgG and a rise of this titer …