Reporter genes facilitating discovery of drugs targeting protozoan parasites
Transfection of protozoan parasites, such as Plasmodium, Leishmania, Trypanosoma and
Toxoplasma, with various reporter gene constructs, has revolutionized studies to understand …
Toxoplasma, with various reporter gene constructs, has revolutionized studies to understand …
Current practice in bicistronic ires reporter use: A systematic review
GGH van den Akker, F Zacchini… - International Journal of …, 2021 - mdpi.com
Bicistronic reporter assays have been instrumental for transgene expression, understanding
of internal ribosomal entry site (IRES) translation, and identification of novel cap …
of internal ribosomal entry site (IRES) translation, and identification of novel cap …
Large-scale generation of human iPSC-derived neural stem cells/early neural progenitor cells and their neuronal differentiation
L D'Aiuto, Y Zhi, D Kumar Das, MR Wilcox… - …, 2014 - Taylor & Francis
Induced pluripotent stem cell (iPSC)-based technologies offer an unprecedented opportunity
to perform high-throughput screening of novel drugs for neurological and …
to perform high-throughput screening of novel drugs for neurological and …
Fluorescent Leishmania species: development of stable GFP expression and its application for in vitro and in vivo studies
Reporter genes have proved to be an excellent tool for studying disease progression.
Recently, the green fluorescent protein (GFP) ability to quantitatively monitor gene …
Recently, the green fluorescent protein (GFP) ability to quantitatively monitor gene …
Human induced pluripotent stem cell-derived models to investigate human cytomegalovirus infection in neural cells
L D'Aiuto, R Di Maio, B Heath, G Raimondi… - PLoS …, 2012 - journals.plos.org
Human cytomegalovirus (HCMV) infection is one of the leading prenatal causes of
congenital mental retardation and deformities world-wide. Access to cultured human …
congenital mental retardation and deformities world-wide. Access to cultured human …
Genetic and morphological features of human iPSC-derived neurons with chromosome 15q11. 2 (BP1-BP2) deletions
Background: Copy number variation on chromosome 15q11. 2 (BP1-BP2) causes a deletion
of CYFIP1, NIPA1, NIPA2 and TUBGCP5. Furthermore, it also affects brain structure and …
of CYFIP1, NIPA1, NIPA2 and TUBGCP5. Furthermore, it also affects brain structure and …
Mouse ES cells overexpressing DNMT1 produce abnormal neurons with upregulated NMDA/NR1 subunit
High levels of DNA methyltransferase 1 (DNMT1), hypermethylation, and downregulation of
GAD 67 and reelin have been described in GABAergic interneurons of patients with …
GAD 67 and reelin have been described in GABAergic interneurons of patients with …
Low-density neuronal cultures from human induced pluripotent stem cells
P Dimitrion, Y Zhi, D Clayton, GL Apodaca… - Molecular …, 2017 - karger.com
Induced pluripotent stem cell (iPSC)-based technologies offer an unprecedented possibility
to investigate defects occurring during neuronal differentiation in neuropsychiatric and …
to investigate defects occurring during neuronal differentiation in neuropsychiatric and …
Nicotine exposure during differentiation causes inhibition of N-myc expression
A Ben-Yehudah, BM Campanaro, LM Wakefield… - Respiratory …, 2013 - Springer
Background The ability of chemicals to disrupt neonatal development can be studied using
embryonic stem cells (ESC). One such chemical is nicotine. Prenatal nicotine exposure is …
embryonic stem cells (ESC). One such chemical is nicotine. Prenatal nicotine exposure is …
Investigations into the role of RNA modification in the function of the c-Myc IRES
A Goodacre - 2024 - repository.cam.ac.uk
During patho-physiological conditions, which lead to cell stress, there is a rapid and large
reduction in protein synthesis rates. This is mediated, in part, by a decrease in cap …
reduction in protein synthesis rates. This is mediated, in part, by a decrease in cap …