The societal need for new central nervous system (CNS) medicines is substantial, because
of the global increase in life expectancy and the accompanying increase in age-related CNS …

Viscoelasticity and its alteration in time and space has turned out to act as a key element in
fundamental biological processes in living systems, such as morphogenesis and motility …

Background Receptor-mediated transcytosis is one of the major routes for drug delivery of
large molecules into the brain. The aim of this study was to develop a novel model of the …

The delivery of therapeutics to the central nervous system remains a major challenge in part
due to the presence of the blood–brain barrier (BBB). Recently, cell-derived vesicles …

The blood-brain barrier (BBB) is a critical structure that serves as the gatekeeper between
the central nervous system and the rest of the body. It is the responsibility of the BBB to …

We describe here the design and implementation of an in vitro microvascular open model
system using human brain microvascular endothelial cells. The design has several …

Studies of neonatal neural pathologies and development of appropriate therapeutics are
hampered by a lack of relevant in vitro models of neonatal blood-brain barrier (BBB). To …

Abstract Models of biological barriers are important to study physiological functions,
transport mechanisms, drug delivery and pathologies. However, there are only a few …

Objective: To address the hypothesis that physiologic interactions between astrocytes and
endothelial cells (EC) at the blood–brain barrier (BBB) are afflicted by pathogenic …

Background and Objectives To evaluate the pathophysiology of neuromyelitis optica
spectrum disorder (NMOSD) and the therapeutic mechanism and levels of interleukin-6 (IL …