Inflammation is a defensive reaction for external stimuli to the human body and generally
accompanied by immune responses, which is associated with multiple diseases such as …

H2A. Z is a histone variant that provides specific structural and docking-side properties to the
nucleosome, resulting in diverse and specialised molecular and cellular functions. In this …

Histone modifications are implicated in influencing gene expression. We have generated
high-resolution maps for the genome-wide distribution of 20 histone lysine and arginine …

An increasing body of evidence indicates that transcription and splicing are coupled, and it
is accepted that chromatin organization regulates transcription. Little is known about the …

Histone post-translational modifications impact many aspects of chromatin and nuclear
function. Histone H4 Lys 20 methylation (H4K20me) has been implicated in regulating …

SET8 is implicated in transcriptional regulation, heterochromatin formation, genomic
stability, cell‐cycle progression, and development. As such, it is predicted that SET8 might …

Histones undergo several different post-translational modifications that control a variety of
physiological processes. These covalent modifications show substantial cross-regulation …

Complex patterns of histone lysine methylation encode distinct functions within chromatin.
We previously reported that trimethylation of lysine 9 of histone H3 (H3K9) occurs at both …

Methylation of histone H4 at lysine 20 (K20) has been implicated in transcriptional activation,
gene silencing, heterochromatin formation, mitosis, and DNA repair. However, little is known …

The links between obesity in parents and their offspring and the role of genes and a shared
environment are not completely understood. Adipocytokines such as leptin and adiponectin …