Genetics, structure, and function of group A streptococcal pili

M Nakata, B Kreikemeyer - Frontiers in Microbiology, 2021 - frontiersin.org
Streptococcus pyogenes (Group A Streptococcus; GAS) is an exclusively human pathogen.
This bacterial species is responsible for a large variety of infections, ranging from purulent …

Pilus biogenesis of Gram‐positive bacteria: Roles of sortases and implications for assembly

B Khare, S VL Narayana - Protein Science, 2017 - Wiley Online Library
Successful adherence, colonization, and survival of Gram‐positive bacteria require surface
proteins, and multiprotein assemblies called pili. These surface appendages are attractive …

Transglutaminase 3 crosslinks the secreted gel-forming mucus component Mucin-2 and stabilizes the colonic mucus layer

JDA Sharpen, B Dolan, EEL Nyström… - Nature …, 2022 - nature.com
The colonic mucus layer is organized as a two-layered system providing a physical barrier
against pathogens and simultaneously harboring the commensal flora. The factors …

Toxoplasma gondii peptide ligands open the gate of the HLA class I binding groove

C McMurtrey, T Trolle, T Sansom, SG Remesh… - Elife, 2016 - elifesciences.org
HLA class I presentation of pathogen-derived peptide ligands is essential for CD8+ T-cell
recognition of Toxoplasma gondii infected cells. Currently, little data exist pertaining to …

Structural and biochemical studies of an NB-ARC domain from a plant NLR immune receptor

JFC Steele, RK Hughes, MJ Banfield - PloS one, 2019 - journals.plos.org
Plant NLRs are modular immune receptors that trigger rapid cell death in response to
attempted infection by pathogens. A highly conserved n ucleotide-b inding domain shared …

Investigating the effects of cyclic topology on the performance of a plastic degrading enzyme for polyethylene terephthalate degradation

HC Hayes, LYP Luk - Scientific Reports, 2023 - nature.com
Agitation is a commonly encountered stress for enzymes during all stages of production and
application, but investigations that aim to improve their tolerance using topological …

[HTML][HTML] Adhesion and invasion of Streptococcus pyogenes into host cells and clinical relevance of intracellular streptococci

M Rohde, PP Cleary - Streptococcus pyogenes: Basic Biology to …, 2022 - ncbi.nlm.nih.gov
The heterogeneous genus of Streptococci plays an important role in human disease.
Streptococci are estimated to cause 700 million human infections each year worldwide, with …

An internal thioester in a pathogen surface protein mediates covalent host binding

M Walden, JM Edwards, AM Dziewulska, R Bergmann… - Elife, 2015 - elifesciences.org
To cause disease and persist in a host, pathogenic and commensal microbes must adhere
to tissues. Colonization and infection depend on specific molecular interactions at the host …

Tissue tropisms in group A Streptococcus: what virulence factors distinguish pharyngitis from impetigo strains?

DE Bessen - Current opinion in infectious diseases, 2016 - journals.lww.com
The gap between molecular markers of disease (correlation) and virulence mechanisms
(causation) in the establishment of tissue tropisms for GAS infection currently remains wide …

Pilins in Gram‐positive bacteria: a structural perspective

V Krishnan - IUBMB life, 2015 - Wiley Online Library
Pilins or fimbrilins are a class of proteins found in bacterial surface pilus, a hair‐like surface
appendage. Both the Gram‐negative and‐positive bacteria produce pilins to assemble pili …