The present review article offers a detailed account of the design strategies employed for the
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …

Extensive experimental evidence indicates that platelets contribute to tumor cell proliferation
and metastasis through direct interactions and secreted bioactive proteins. Activated …

Epidermal growth factor receptor (EGFR) and its subtype human epidermal growth factor
receptor 2 (HER2) gets activated when its endogenous ligand (s) bind to its ATP binding site …

We studied the three-component condensation of 2-chloraldehyde, acetophenone, and
thiourea in conjunction with HCl, resulting in the formation of a new compound: 4, 5-bis (2 …

This Review describes the existing synthetic approaches for the solid-phase synthesis (SPS)
of differently substituted and fused pyrimidine derivatives. These synthetic strategies are …

The present study provides an overview of the chemistry and biological significance of
pyrimido [4, 5-d] pyrimidine and pyrimido [5, 4-d] pyrimidine analogs as types of bicyclic [6+ …

Abstract Sulfonic acid functionalized 1, 4-diazabicyclo [2.2. 2] octane supported on Merrifield
resin,[MerDABCO-SO 3 H] Cl catalyst was prepared and explored in one-pot four …

Genetic modifications during development of paediatric groups 3 and 4 medulloblastoma
are responsible for their highly metastatic properties and poor patient survival rates …

We analyze the fundamental functions of Prune_1 in brain pathophysiology. We discuss the
importance and maintenance of the function of Prune_1 and how its perturbation influences …

H-Prune hydrolyzes short-chain polyphosphates (PPase activity) together with an hitherto
cAMP-phosphodiesterase (PDE), the latest influencing different human cancers by its …