Development of isatin-thiazolo [3, 2-a] benzimidazole hybrids as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: Synthesis, biological and …
In the current medical era, human health is experiencing numerous challenges, particularly
the human malignancies. Therefore, the therapeutic arsenal for these malignancies is to be …
the human malignancies. Therefore, the therapeutic arsenal for these malignancies is to be …
[HTML][HTML] Structure-based pharmacophore modeling, virtual screening, molecular docking, ADMET, and molecular dynamics (MD) simulation of potential inhibitors of …
L Luo, A Zhong, Q Wang, T Zheng - Marine Drugs, 2021 - mdpi.com
Background: In the past decade, several antibodies directed against the PD-1/PD-L1
interaction have been approved. However, therapeutic antibodies also exhibit some …
interaction have been approved. However, therapeutic antibodies also exhibit some …
In silico identification of novel SARS-COV-2 2′-O-methyltransferase (nsp16) inhibitors: structure-based virtual screening, molecular dynamics simulation and MM …
The novel coronavirus disease COVID-19, caused by the virus SARS CoV-2, has exerted a
significant unprecedented economic and medical crisis, in addition to its impact on the daily …
significant unprecedented economic and medical crisis, in addition to its impact on the daily …
[HTML][HTML] Identification of a New Potential SARS-COV-2 RNA-Dependent RNA Polymerase Inhibitor via Combining Fragment-Based Drug Design, Docking, Molecular …
The world has recently been struck by the SARS-Cov-2 pandemic, a situation that people
have never before experienced. Infections are increasing without reaching a peak. The …
have never before experienced. Infections are increasing without reaching a peak. The …
Design, synthesis, molecular docking and antiproliferative activity of some novel benzothiazole derivatives targeting EGFR/HER2 and TS
Multi-targeted anticancer drugs are in focus as a promising research topic. A new series of
benzothiazoles hybridized with pyrimidine moiety was designed and synthesized using the …
benzothiazoles hybridized with pyrimidine moiety was designed and synthesized using the …
[HTML][HTML] Toward the identification of potential α-ketoamide covalent inhibitors for SARS-CoV-2 main protease: Fragment-based drug design and MM-PBSA …
Since December 2019, the world has been facing the outbreak of the SARS-CoV-2
pandemic that has infected more than 149 million and killed 3.1 million people by 27 April …
pandemic that has infected more than 149 million and killed 3.1 million people by 27 April …
Fenticonazole nitrate loaded trans-novasomes for effective management of tinea corporis: design characterization, in silico study, and exploratory clinical appraisal
The current investigation aimed for loading fenticonazole nitrate (FTN), an antifungal agent
with low aqueous solubility, into trans-novasomes (TNs) for management of tinea corporis …
with low aqueous solubility, into trans-novasomes (TNs) for management of tinea corporis …
[HTML][HTML] Sonophoresis mediated diffusion of caffeine loaded Transcutol® enriched cerosomes for topical management of cellulite
The goal of this research was to augment the deposition of caffeine loaded Transcutol®
enriched cerosomes (TECs) gel for efficient topical treatment of cellulite utilizing the …
enriched cerosomes (TECs) gel for efficient topical treatment of cellulite utilizing the …
[HTML][HTML] In silico identification of potential SARS COV-2 2′-O-methyltransferase inhibitor: Fragment-based screening approach and MM-PBSA calculations
In the present era, there are many efforts trying to face the emerging and successive waves
of the COVID-19 pandemic. This has led to considering new and unusual targets for SARS …
of the COVID-19 pandemic. This has led to considering new and unusual targets for SARS …
Insights into structural dynamics of allosteric binding sites in HCV RNA-dependent RNA polymerase
Inhibition of the viral RNA-dependent RNA polymerase (RdRp) to resolve chronic infection is
a useful therapeutic strategy against Hepatitis C virus (HCV). Non-nucleoside inhibitors …
a useful therapeutic strategy against Hepatitis C virus (HCV). Non-nucleoside inhibitors …