The complex molecular genetics of familial hypercholesterolaemia

AJ Berberich, RA Hegele - Nature Reviews Cardiology, 2019 - nature.com
Familial hypercholesterolaemia is the most commonly encountered genetic condition that
predisposes individuals to premature cardiovascular disease. Nevertheless, most patients …

Familial hypercholesterolaemia

JC Defesche, SS Gidding, M Harada-Shiba… - Nature reviews Disease …, 2017 - nature.com
Familial hypercholesterolaemia is a common inherited disorder characterized by abnormally
elevated serum levels of low-density lipoprotein (LDL) cholesterol from birth, which in time …

Familial hypercholesterolaemia: evolving knowledge for designing adaptive models of care

GF Watts, SS Gidding, P Mata, J Pang… - Nature Reviews …, 2020 - nature.com
Optimal care for familial hypercholesterolaemia (FH) requires patient-centred management,
multidisciplinary teamwork, involvement of primary care practitioners, patient networks …

Familial hypercholesterolemia-risk-score: a new score predicting cardiovascular events and cardiovascular mortality in familial hypercholesterolemia

M Paquette, S Bernard, B Cariou… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Familial hypercholesterolemia (FH) is associated with a high risk of premature
atherosclerotic cardiovascular disease (ASCVD). However, this risk is highly heterogeneous …

Canadian Cardiovascular Society position statement on familial hypercholesterolemia: update 2018

LR Brunham, I Ruel, S Aljenedil, JB Rivière… - Canadian Journal of …, 2018 - Elsevier
Familial hypercholesterolemia (FH) is the most common monogenic disorder causing
premature atherosclerotic cardiovascular disease. It affects 1 in 250 individuals worldwide …

[HTML][HTML] Recent advances in the management and implementation of care for familial hypercholesterolaemia

NSR Lan, A Bajaj, GF Watts, M Cuchel - Pharmacological research, 2023 - Elsevier
Familial hypercholesterolaemia (FH) is a common autosomal semi-dominant and highly
penetrant disorder of the low-density lipoprotein (LDL) receptor pathway, characterised by …

Risk factors for cardiovascular disease in heterozygous familial hypercholesterolemia: A systematic review and meta-analysis

LE Akioyamen, J Genest, A Chu, H Inibhunu… - Journal of clinical …, 2019 - Elsevier
Background Current data from individual studies present conflicting evidence about the
relationship between risk factors and cardiovascular disease (CVD) in heterozygous familial …

Diabetes and familial hypercholesterolemia: interplay between lipid and glucose metabolism

AM González-Lleó, RM Sánchez-Hernández… - Nutrients, 2022 - mdpi.com
Familial hypercholesterolemia (FH) is a genetic disease characterized by high low-density
lipoprotein (LDL) cholesterol (LDL-c) concentrations that increase cardiovascular risk and …

Epidemiology of familial hypercholesterolaemia: community and clinical

AJ Vallejo-Vaz, KK Ray - Atherosclerosis, 2018 - Elsevier
Familial hypercholesterolaemia (FH) is a genetic disorder affecting the metabolism of low-
density lipoprotein (LDL) particles, leading to high LDL-cholesterol levels maintained over …

Update of the Brazilian guideline for familial hypercholesterolemia–2021

MCO Izar, VZR Giraldez, A Bertolami… - Arquivos brasileiros de …, 2021 - SciELO Brasil
Financial declaration A-Economically relevant payments of any kind made to (i) you,(ii) your
spouse/partner or any other person living with you,(iii) any legal person in which any of …