Mitochondria are associated with various cellular activities critical to homeostasis,
particularly in the nervous system. The plastic architecture of the mitochondrial network and …

Mitochondria play key roles in bioenergetics, metabolism, and signaling; therefore, stable
mitochondrial function is essential for cell survival, particularly in energy-intensive neuronal …

The toxicity of misfolded proteins and mitochondrial dysfunction are pivotal factors that
promote age-associated functional neuronal decline and neurodegenerative disease …

Mitochondria are essential for tumor growth and progression. However, the heavy demand
for mitochondrial activity in cancer leads to increased production of mitochondrial reactive …

Most proteins must fold into defined three-dimensional structures to gain functional activity.
But in the cellular environment, newly synthesized proteins are at great risk of aberrant …

Proteinopathy and excessive production of reactive oxygen species (ROS), which are the
principal features observed in the Alzheimer's disease (AD) brain, contribute to neuronal …

Alzheimer's disease and Parkinson's disease are two common neurodegenerative diseases
of the elderly people that have devastating effects in terms of morbidity and mortality. The …

Here, we use single-molecule techniques to study the aggregation of α-synuclein, the
protein whose misfolding and deposition is associated with Parkinson's disease. We identify …

Ten years after the first overview of a complete plant Hsf family was presented for
Arabidopsis thaliana by Nover et al.[1], we compiled data for 252 Hsfs from nine plant …

The biological functions of proteins are governed by their three-dimensional fold. Protein
folding, maintenance of proteome integrity, and protein homeostasis (proteostasis) critically …