Vanadium and tungsten derivatives as antidiabetic agents: a review of their toxic effects
JL Domingo - Biological trace element research, 2002 - Springer
Tungstate is an oxyanion that has biological similarities to vanadate. In recent years, a
number of studies have shown the antidiabetic effects of oral tungstate in animal models of …
number of studies have shown the antidiabetic effects of oral tungstate in animal models of …
Insulin-mimetic effects of vanadate: possible implications for future treatment of diabetes
Y Shechter - Diabetes, 1990 - Am Diabetes Assoc
Vanadate ions, low-molecular-weight phosphate analogues, mimic most of the rapid actions
of insulin in various cell types. When administered orally to diabetic hyperglycemic rats …
of insulin in various cell types. When administered orally to diabetic hyperglycemic rats …
Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics.
Twelve peroxovanadium (pV) compounds, each containing an oxo ligand, one or two
peroxo anions, and an ancillary ligand in the inner coordination sphere of V, were …
peroxo anions, and an ancillary ligand in the inner coordination sphere of V, were …
Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus.
N Cohen, M Halberstam, P Shlimovich… - The Journal of …, 1995 - Am Soc Clin Investig
We examined the in vivo metabolic effects of vanadyl sulfate (VS) in non-insulin-dependent
diabetes mellitus (NIDDM). Six NIDDM subjects treated with diet and/or sulfonylureas were …
diabetes mellitus (NIDDM). Six NIDDM subjects treated with diet and/or sulfonylureas were …
Insulino‐mimetic and anti‐diabetic effects of vanadium compounds
AK Srivastava, MZ Mehdi - Diabetic medicine, 2005 - Wiley Online Library
Compounds of the trace element vanadium exert various insulin‐like effects in in vitro and in
vivo systems. These include their ability to improve glucose homeostasis and insulin …
vivo systems. These include their ability to improve glucose homeostasis and insulin …
Selenium, vanadium, and chromium as micronutrients to improve metabolic syndrome
Trace metals play an important role in the proper functioning of carbohydrate and lipid
metabolism. Some of the trace metals are thus essential for maintaining homeostasis, while …
metabolism. Some of the trace metals are thus essential for maintaining homeostasis, while …
Vanadium and diabetes
P Poucheret, S Verma, MD Grynpas… - Molecular and Cellular …, 1998 - Springer
We demonstrated in 1985 that vanadium administered in the drinking water to streptozotocin
(STZ) diabetic rats restored elevated blood glucose to normal. Subsequent studies have …
(STZ) diabetic rats restored elevated blood glucose to normal. Subsequent studies have …
Metabolic effects of vanadyl sulfate in humans with non—insulin-dependent diabetes mellitus: in vivo and in vitro studies
To investigate the efficacy and mechanism of action of vanadium salts as oral hypoglycemic
agents, 16 type 2 diabetic patients were studied before and after 6 weeks of vanadyl sulfate …
agents, 16 type 2 diabetic patients were studied before and after 6 weeks of vanadyl sulfate …
Anti-diabetic and toxic effects of vanadium compounds
AK Srivastava - Molecular and Cellular Biochemistry, 2000 - Springer
Compounds of the trace element vanadium have been shown to mimic insulin in in vitro and
in vivo systems. These compounds have been found to exert anti-diabetic effects in rodent …
in vivo systems. These compounds have been found to exert anti-diabetic effects in rodent …
Mechanism of insulin sensitization by BMOV (bis maltolato oxo vanadium); unliganded vanadium (VO4) as the active component
KG Peters, MG Davis, BW Howard, M Pokross… - Journal of Inorganic …, 2003 - Elsevier
Organovanadium compounds have been shown to be insulin sensitizers in vitro and in vivo.
One potential biochemical mechanism for insulin sensitization by these compounds is that …
One potential biochemical mechanism for insulin sensitization by these compounds is that …