Vanadium and tungsten derivatives as antidiabetic agents: a review of their toxic effects

JL Domingo - Biological trace element research, 2002 - Springer
Tungstate is an oxyanion that has biological similarities to vanadate. In recent years, a
number of studies have shown the antidiabetic effects of oral tungstate in animal models of …

Insulin-mimetic effects of vanadate: possible implications for future treatment of diabetes

Y Shechter - Diabetes, 1990 - Am Diabetes Assoc
Vanadate ions, low-molecular-weight phosphate analogues, mimic most of the rapid actions
of insulin in various cell types. When administered orally to diabetic hyperglycemic rats …

Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics.

BI Posner, R Faure, JW Burgess, AP Bevan… - Journal of Biological …, 1994 - ASBMB
Twelve peroxovanadium (pV) compounds, each containing an oxo ligand, one or two
peroxo anions, and an ancillary ligand in the inner coordination sphere of V, were …

Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus.

N Cohen, M Halberstam, P Shlimovich… - The Journal of …, 1995 - Am Soc Clin Investig
We examined the in vivo metabolic effects of vanadyl sulfate (VS) in non-insulin-dependent
diabetes mellitus (NIDDM). Six NIDDM subjects treated with diet and/or sulfonylureas were …

Insulino‐mimetic and anti‐diabetic effects of vanadium compounds

AK Srivastava, MZ Mehdi - Diabetic medicine, 2005 - Wiley Online Library
Compounds of the trace element vanadium exert various insulin‐like effects in in vitro and in
vivo systems. These include their ability to improve glucose homeostasis and insulin …

Selenium, vanadium, and chromium as micronutrients to improve metabolic syndrome

SK Panchal, S Wanyonyi, L Brown - Current hypertension reports, 2017 - Springer
Trace metals play an important role in the proper functioning of carbohydrate and lipid
metabolism. Some of the trace metals are thus essential for maintaining homeostasis, while …

Vanadium and diabetes

P Poucheret, S Verma, MD Grynpas… - Molecular and Cellular …, 1998 - Springer
We demonstrated in 1985 that vanadium administered in the drinking water to streptozotocin
(STZ) diabetic rats restored elevated blood glucose to normal. Subsequent studies have …

Metabolic effects of vanadyl sulfate in humans with non—insulin-dependent diabetes mellitus: in vivo and in vitro studies

AB Goldfine, ME Patti, L Zuberi, BJ Goldstein… - Metabolism, 2000 - Elsevier
To investigate the efficacy and mechanism of action of vanadium salts as oral hypoglycemic
agents, 16 type 2 diabetic patients were studied before and after 6 weeks of vanadyl sulfate …

Anti-diabetic and toxic effects of vanadium compounds

AK Srivastava - Molecular and Cellular Biochemistry, 2000 - Springer
Compounds of the trace element vanadium have been shown to mimic insulin in in vitro and
in vivo systems. These compounds have been found to exert anti-diabetic effects in rodent …

Mechanism of insulin sensitization by BMOV (bis maltolato oxo vanadium); unliganded vanadium (VO4) as the active component

KG Peters, MG Davis, BW Howard, M Pokross… - Journal of Inorganic …, 2003 - Elsevier
Organovanadium compounds have been shown to be insulin sensitizers in vitro and in vivo.
One potential biochemical mechanism for insulin sensitization by these compounds is that …