The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic,
maternally inherited, energy-transforming, biosynthetic, and signaling organelles that …

Metabolism of cancer cells is geared toward biomass production and proliferation. Since the
metabolic resources within the local tissue are finite, this can lead to nutrient depletion and …

The mitochondrial oxidative phosphorylation system is central to cellular metabolism. It
comprises five enzymatic complexes and two mobile electron carriers that work in a …

The tricarboxylic acid (TCA) cycle, otherwise known as the Krebs cycle, is a central
metabolic pathway that performs the essential function of oxidizing nutrients to support …

Nicotinamide adenine dinucleotide, in its oxidized (NAD+) and reduced (NADH) forms, is a
reduction–oxidation (redox) co-factor and substrate for signalling enzymes that have …

Summary NAD (H) and NADP (H) have traditionally been viewed as co-factors (or co-
enzymes) involved in a myriad of oxidation-reduction reactions including the electron …

Metabolic anomalies contribute to tissue dysfunction. Current metabolism research spans
from organelles to populations, and new technologies can accommodate investigation …

Nicotinamide adenine dinucleotide (NAD+) is a central metabolite involved in energy and
redox homeostasis as well as in DNA repair and protein deacetylation reactions …

Depletion of nicotinamide adenine dinucleotide (NAD+), a central redox cofactor and the
substrate of key metabolic enzymes, is the causative factor of a number of inherited and …

Measurement of oxygen consumption is a powerful and uniquely informative experimental
technique. It can help identify mitochondrial mechanisms of action following pharmacologic …