It has been 70 years since the name inhibin was used to describe a gonadal factor that
negatively regulated pituitary hormone secretion. The majority of this period was required to …

Activins, cytokine members of the transforming growth factor-β superfamily, have various
effects on many physiological processes, including cell proliferation, cell death, metabolism …

The precise regulation of the anterior pituitary is achieved by the cell-specific and combined
actions of central, peripheral and local factors. Activins, inhibins, and follistatins were first …

Follicle-stimulating hormone (FSH) is a glycoprotein hormone produced by gonadotropes in
the anterior pituitary that plays a central role in controlling ovarian folliculogenesis and …

Activins and inhibins, members of the transforming growth factor-beta family are able to
stimulate and inhibit, respectively, FSH synthesis and release. Other members of this …

Exposure of female sheep fetuses to excess testosterone (T) during early to midgestation
produces postnatal hypergonadotropism manifest as a selective increase in LH. This …

To examine in vivo, the local effects of inhibins and activins within the anterior pituitary,
independent of their endocrine effects exerted from the gonad, in mediating FSH …

Folliculostellate cells of the anterior pituitary are postulated to be an important source of
factors, such as follistatin, that regulate pituitary function by intercellular communication. To …

Activin-stimulated FSH synthesis and secretion from the pituitary gonadotrope is negatively
modulated by ovarian inhibin; however, the cellular mechanism of inhibin antagonism is …

Both GnRH and activin are crucial for the correct function of pituitary gonadotrope cells.
GnRH regulates LH and FSH synthesis and secretion and gonadotrope proliferation …