Hematopoietic stem cells (HSCs) undergo successive lineage commitment steps to
generate megakaryocytes (MKs) in a process referred to as megakaryopoiesis. MKs …

Since the discovery of spliceosome mutations in myeloid malignancies, abnormal pre-
mRNA splicing, which has been well studied in various cancers, has attracted novel interest …

Acute megakaryocytic leukemia (AMKL) is a clinically heterogeneous subtype of acute
myeloid leukemia characterized by unrestricted megakaryoblast proliferation and poor …

RNA-binding protein Musashi-2 (Msi2) is known to play a critical role in leukemogenesis
and contributes to poor clinical prognosis in acute myeloid leukemia (AML). However, the …

An abnormal expression of poly (ADP-ribose) polymerase 1 (PARP-1) has been described
in many tumors. PARP-1 promotes tumorigenesis and cancer progression by acting on …

Lipopolysaccharide (LPS) induces platelet activation and enhances platelet sensitivity to
aggregation, which might alter platelet counts. We found that serial doses of micro …

Danggui Sini decoction (DSD), a famous Chinese medicine, has been used therapeutically
in various diseases. In this study, we tried to investigate whether and how DSD could …

Cryptosporidium spp. are important causes of diarrhea in humans, ruminants, and other
mammals. Comparative genomic analysis indicated that genetically related and host …

Cytokine and cytokine receptors are important regulators of hematopoiesis. Hematopoietic
stem cells (HSCs) and progenitors differentiate into the myeloid or lymphoid lineage in …

Background To analyze the ways and methods of signaling pathways in regulating cell cycle
progression of NIH3T3 at transcriptional level, we modeled cell cycle of NIH3T3 and found …