Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic
regulation is a heritable change in gene expressions independent of nucleotide sequence …

Cancer cells display pervasive changes in DNA methylation, disrupted patterns of histone
posttranslational modification, chromatin composition or organization and regulatory …

Changes in modern lifestyle provoke a series of metabolic stresses such as hyperlipidemia.
Excessive free fatty acids induce cardiomyocyte metabolic reprogramming and …

Histone demethylation is a key post-translational modification of chromatin, and its
dysregulation affects a wide array of nuclear activities including the maintenance of genome …

Childhood cancer is considered rare, corresponding to~ 3% of all malignant neoplasms in
the human population. The World Health Organization (WHO) reports a universal …

Summary Prostaglandin E 2 (PGE 2) promotes tumor cell proliferation, migration, and
invasion, fostering an inflammation-enriched microenvironment that facilitates angiogenesis …

Recent studies uncovered the emerging roles of SAPCD2 (suppressor anaphase-promoting
complex domain containing 2) in several types of human cancer. However, the functions and …

Drug resistance remains the greatest challenge in improving outcomes for cancer patients
who receive chemotherapy and targeted therapy. Surmounting evidence suggests that a …

Bone marrow mesenchymal stem cells (BMSCs) have strong regenerative potential and
show good application prospects for treating clinical diseases. However, in the process of …

Background: Neuroblastoma (NB) is a childhood cancer originating from immature nerve
cells in the sympathetic nervous system. Current clinical and molecular subtyping methods …