Genetics of circadian rhythms and sleep in human health and disease
Circadian rhythms and sleep are fundamental biological processes integral to human
health. Their disruption is associated with detrimental physiological consequences …
health. Their disruption is associated with detrimental physiological consequences …
Molecular mechanisms and physiological importance of circadian rhythms
A Patke, MW Young, S Axelrod - Nature reviews Molecular cell biology, 2020 - nature.com
To accommodate daily recurring environmental changes, animals show cyclic variations in
behaviour and physiology, which include prominent behavioural states such as sleep–wake …
behaviour and physiology, which include prominent behavioural states such as sleep–wake …
Circadian mechanisms in medicine
Circadian Mechanisms in Medicine Molecular insights into diurnal variations in human
physiology and behavior are extending our understanding of a wide range of disease …
physiology and behavior are extending our understanding of a wide range of disease …
Generation of circadian rhythms in the suprachiasmatic nucleus
MH Hastings, ES Maywood… - Nature Reviews …, 2018 - nature.com
The suprachiasmatic nucleus (SCN) of the hypothalamus is remarkable. Despite numbering
only about 10,000 neurons on each side of the third ventricle, the SCN is our principal …
only about 10,000 neurons on each side of the third ventricle, the SCN is our principal …
Genomics of circadian rhythms in health and disease
F Rijo-Ferreira, JS Takahashi - Genome medicine, 2019 - Springer
Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral
processes. The central circadian clock exerts control over myriad aspects of mammalian …
processes. The central circadian clock exerts control over myriad aspects of mammalian …
Circadian clock genes and the transcriptional architecture of the clock mechanism
KH Cox, JS Takahashi - Journal of molecular endocrinology, 2019 - jme.bioscientifica.com
The mammalian circadian clock has evolved as an adaptation to the 24-h light/darkness
cycle on earth. Maintaining cellular activities in synchrony with the activities of the organism …
cycle on earth. Maintaining cellular activities in synchrony with the activities of the organism …
Circadian rhythm and sleep disruption: causes, metabolic consequences, and countermeasures
Abstract Circadian (∼ 24-hour) timing systems pervade all kingdoms of life and temporally
optimize behavior and physiology in humans. Relatively recent changes to our …
optimize behavior and physiology in humans. Relatively recent changes to our …
Cell-autonomous clock of astrocytes drives circadian behavior in mammals
M Brancaccio, MD Edwards, AP Patton, NJ Smyllie… - Science, 2019 - science.org
Circadian (~ 24-hour) rhythms depend on intracellular transcription-translation negative
feedback loops (TTFLs). How these self-sustained cellular clocks achieve multicellular …
feedback loops (TTFLs). How these self-sustained cellular clocks achieve multicellular …
The functional and clinical significance of the 24-hour rhythm of circulating glucocorticoids
Adrenal glucocorticoids are major modulators of multiple functions, including energy
metabolism, stress responses, immunity, and cognition. The endogenous secretion of …
metabolism, stress responses, immunity, and cognition. The endogenous secretion of …
Molecular architecture of the mammalian circadian clock
CL Partch, CB Green, JS Takahashi - Trends in cell biology, 2014 - cell.com
Circadian clocks coordinate physiology and behavior with the 24h solar day to provide
temporal homeostasis with the external environment. The molecular clocks that drive these …
temporal homeostasis with the external environment. The molecular clocks that drive these …