Machine learning for synthetic data generation: a review

Y Lu, M Shen, H Wang, X Wang, C van Rechem… - arXiv preprint arXiv …, 2023 - arxiv.org
Machine learning heavily relies on data, but real-world applications often encounter various
data-related issues. These include data of poor quality, insufficient data points leading to …

Uncertainty quantification on clinical trial outcome prediction

T Chen, Y Lu, N Hao, C Van Rechem, J Chen… - arXiv preprint arXiv …, 2024 - arxiv.org
The importance of uncertainty quantification is increasingly recognized in the diverse field of
machine learning. Accurately assessing model prediction uncertainty can help provide …

Trialbench: Multi-modal artificial intelligence-ready clinical trial datasets

J Chen, Y Hu, Y Wang, Y Lu, X Cao, M Lin, H Xu… - arXiv preprint arXiv …, 2024 - arxiv.org
Clinical trials are pivotal for developing new medical treatments, yet they typically pose
some risks such as patient mortality, adverse events, and enrollment failure that waste …

Trends in machine learning and electroencephalogram (EEG): a review for undergraduate researchers

NK Murungi, MV Pham, X Dai, X Qu - International Conference on Human …, 2023 - Springer
This paper presents a systematic literature review on Brain-Computer Interfaces (BCIs) in
the context of Machine Learning. Our focus is on Electroencephalography (EEG) research …

Trialdura: Hierarchical attention transformer for interpretable clinical trial duration prediction

L Yue, J Li, S Xing, MZ Islam, B Xia, T Fu… - arXiv preprint arXiv …, 2024 - arxiv.org
The clinical trial process, a critical phase in drug development, is essential for developing
new treatments. The primary goal of interventional clinical trials is to evaluate the safety and …

PASSer2. 0: accurate prediction of protein allosteric sites through automated machine learning

S Xiao, H Tian, P Tao - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Allostery is a fundamental process in regulating protein activities. The discovery, design, and
development of allosteric drugs demand better identification of allosteric sites. Several …

Trialenroll: Predicting clinical trial enrollment success with deep & cross network and large language models

L Yue, S Xing, J Chen, T Fu - Proceedings of the 15th ACM International …, 2024 - dl.acm.org
Clinical trials need to recruit a sufficient number of volunteer patients to demonstrate the
statistical power of the treatment (eg, a new drug) in curing a certain disease. Clinical trial …

COT: an efficient and accurate method for detecting marker genes among many subtypes

Y Lu, CT Wu, SJ Parker, Z Cheng… - Bioinformatics …, 2022 - academic.oup.com
Motivation Ideally, a molecularly distinct subtype would be composed of molecular features
that are expressed uniquely in the subtype of interest but in no others—so-called marker …

Drugclip: Contrastive drug-disease interaction for drug repurposing

Y Lu, Y Hu, C Li - arXiv preprint arXiv:2407.02265, 2024 - arxiv.org
Bringing a novel drug from the original idea to market typically requires more than ten years
and billions of dollars. To alleviate the heavy burden, a natural idea is to reuse the approved …

Uncertainty quantification and interpretability for clinical trial approval prediction

Y Lu, T Chen, N Hao, C Van Rechem, J Chen… - Health Data …, 2024 - spj.science.org
Background: Clinical trial is a crucial step in the development of a new therapy (eg,
medication) and is remarkably expensive and time-consuming. Forecasting the approval of …