Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …

Liver fibrosis is an abnormal wound repair response caused by a variety of chronic liver
injuries, which is characterized by over-deposition of diffuse extracellular matrix (ECM) and …

Fibrosis, or tissue scarring, develops as a pathological deviation from the physiological
wound healing response and can occur in various organs such as the heart, lung, liver …

Cardiac fibrosis is central to the pathology of heart failure, particularly heart failure with
preserved ejection fraction (HF p EF). Irrespective of the underlying profibrotic condition (eg …

Quantifying glutathione (GSH) in cells and organisms is of great significance for
understanding the mechanism of oxidative stress in various physiological and pathological …

Liver fibrosis is a serious liver disease associated with high morbidity and mortality. The
activation of hepatic stellate cells (HSCs) and the overproduction of extracellular matrix …

Liver cancer is one of the main causes of death related to cancer worldwide; its etiology is
related with infections by C or B hepatitis virus, alcohol consumption, smoking, obesity …

To study the role of pirfenidone in rats exposed to silica dust, we established the rat silicosis
model with 50 mg/ml silica by intratracheal instillation. From the first day after silica …

Obesity causes extracellular matrix (ECM) remodelling which can develop into serious
pathology and fibrosis, having metabolic effects in insulin-sensitive tissues. The ECM …

The incidence rate and mortality of liver fibrosis caused by various etiologies are high
throughout the world. Liver fibrosis, the subsequent cirrhosis and other serious related …