General anesthetics depress excitatory and/or enhance inhibitory synaptic transmission
principally by modulating the function of glutamatergic or GABAergic synapses, respectively …

Long-term consequences of anesthetic exposure in humans are not well understood. It is
possible that alterations in brain function occur beyond the initial anesthetic administration …

Background: The pathophysiological mechanisms underlying postoperative cognitive
dysfunction (POCD) remain unclear over the years. Neuroinflammation caused by surgery …

Although it is known that isoflurane exposure or surgery leads to post‐operative cognitive
dysfunction in aged rodents, there are few clinical interventions and treatments available to …

Aims This study was designed to investigate the role of NR2B and the contribution of DNA
methylation to NR2B expression in the pathogenesis of PND. Methods Eighteen‐month‐old …

Postoperative cognitive dysfunction (POCD) is a decline in memory following anaesthesia
and surgery in elderly patients. While often reversible, it consumes medical resources …

Postoperative cognitive dysfunction (POCD) is a clinical phenomenon characterized by
cognitive deficits in patients after anesthesia and surgery, especially in geriatric surgical …

Mitochondrial dysfunction has been linked to the earliest pathogenesis of isoflurane-induced
cognitive impairments in developing or aging mammalian brain. However, its molecular …

Isoflurane is a commonly used inhalational anesthetic, clinically and in animal experimental
studies. Although it has been reported as safe, recent findings suggest that despite …

Postoperative cognitive dysfunction (POCD) is increasingly being recognized as an
important clinical syndrome. Although it has been documented that volatile anesthetics …