Protein kinase C and casein kinase substrate in neurons (PACSINs), or syndapins (synaptic
dynamin‐associated proteins), are a family of proteins involved in the regulation of cell …

Azathioprine and 6-mercaptopurine, often referred to as thiopurine compounds, are
commonly used in the management of inflammatory bowel disease. However, patients …

The efficacy of thiopurines, including azathioprine (AZA) and 6-mercaptopurine (6MP), has
been demonstrated for the treatment of inflammatory bowel disease (IBD). The most …

Pediatric acute lymphoblastic leukemia (ALL) affects a substantial number of children every
year and requires a long and rigorous course of chemotherapy treatments in three stages …

Personalized medicine is focused on research disciplines which contribute to the
individualization of therapy, like pharmacogenomics and pharmacotranscriptomics. Acute …

Acute lymphoblastic leukemia (ALL) is the major pediatric cancer in developed countries.
Although treatment outcome has improved owing to advances in chemotherapy, there is still …

We performed a genomewide association study (GWAS) of primary erythrocyte thiopurine S‐
methyltransferase (TPMT) activity in children with leukemia (n= 1,026). Adjusting for age and …

During the 3rd congress of the European Society of Pharmacogenomics and Personalised
Therapy (ESPT) in Budapest in 2015, a preliminary meeting was held aimed at establishing …

Azathioprine and 6-mercaptopurine remain pivotal therapies for the maintenance of disease
remission in patients with Crohn's disease and ulcerative colitis. While thiopurine S …

Introduction: Inflammatory bowel disease is a chronic inflammation of the gut whose
pathogenesis is still unclear. Although no curative therapy is currently available, a number of …