Multi-dimensional omics profiling continues to illuminate the complexity of cellular
processes. Because of difficult mechanistic interpretation of phenotypes induced by slow …

Highlights•Optogenetic tools provide precise spatial and temporal control of GPCR
signaling.•Light-sensitive proteins can be engineered for GPCR-specific applications.• …

During cell migration and polarization, numerous signal transduction and cytoskeletal
components self-organize to generate localized protrusions. Although biochemical and …

Cells migrate by applying rearward forces against extracellular media. It is unclear how this
is achieved in amoeboid migration, which lacks adhesions typical of lamellipodia-driven …

Light is extensively used to study cells in real time (live cell imaging), separate cells using
fluorescence activated cell sorting (FACS) and control cellular functions with light sensitive …

Despite the fact that roughly 40% of all US Food and Drug Administration (FDA)-approved
pharmacological therapeutics target G protein–coupled receptors (GPCRs), there remains a …

Migratory immune cells use intracellular signaling networks to generate and orient spatially
polarized responses to extracellular cues. The monomeric G protein Cdc42 is believed to …

This perspective article highlights the challenges in the theoretical description of
photoreceptor proteins using multiscale modeling, as discussed at the CECAM workshop in …

ABSTRACT Glucose transporter 4 (GLUT4; also known as SLC2A4) resides on intracellular
vesicles in muscle and adipose cells, and translocates to the plasma membrane in response …

Simple Summary Glucose metabolism was the first metabolic pathway to be discovered and
serves a central role across all life by generating energy. Cancer cells hijack glycolysis to …