Pharmacological modulation of mitochondrial ion channels
The field of mitochondrial ion channels has undergone a rapid development during the last
three decades, due to the molecular identification of some of the channels residing in the …
three decades, due to the molecular identification of some of the channels residing in the …
[HTML][HTML] Impact of intracellular ion channels on cancer development and progression
Cancer research is nowadays focused on the identification of possible new targets in order
to try to develop new drugs for curing untreatable tumors. Ion channels have emerged as …
to try to develop new drugs for curing untreatable tumors. Ion channels have emerged as …
A novel multi-component approach to the synthesis of pyrrolo [2, 1-a] isoquinoline derivatives
LG Voskressensky, TN Borisova, MD Matveeva… - RSC Advances, 2016 - pubs.rsc.org
A novel multi-component approach to the synthesis of pyrrolo[2,1- a ]isoquinoline derivatives -
RSC Advances (RSC Publishing) DOI:10.1039/C6RA15810B Royal Society of Chemistry …
RSC Advances (RSC Publishing) DOI:10.1039/C6RA15810B Royal Society of Chemistry …
TASK channels pharmacology: new challenges in drug design
Rational drug design targeting ion channels is an exciting and always evolving research
field. New medicinal chemistry strategies are being implemented to explore the wild …
field. New medicinal chemistry strategies are being implemented to explore the wild …
[HTML][HTML] Discovery of novel TASK-3 channel blockers using a pharmacophore-based virtual screening
TASK-3 is a two-pore domain potassium (K2P) channel highly expressed in the
hippocampus, cerebellum, and cortex. TASK-3 has been identified as an oncogenic …
hippocampus, cerebellum, and cortex. TASK-3 has been identified as an oncogenic …
[HTML][HTML] 5-(Indol-2-yl)pyrazolo[3,4-b]pyridines as a New Family of TASK-3 Channel Blockers: A Pharmacophore-Based Regioselective Synthesis
D Ramírez, M Mejia-Gutierrez, B Insuasty, S Rinné… - Molecules, 2021 - mdpi.com
TASK channels belong to the two-pore-domain potassium (K2P) channels subfamily. These
channels modulate cellular excitability, input resistance, and response to synaptic …
channels modulate cellular excitability, input resistance, and response to synaptic …
Pathophysiological role of mitochondrial potassium channels and their modulation by drugs
V Citi, V Calderone, A Martelli… - Current medicinal …, 2018 - ingentaconnect.com
Background: Mitochondria play a central role in ATP-generating processes. Indeed, in
mammalian tissues, up to 90% of ATP is generated by mitochondria through the process of …
mammalian tissues, up to 90% of ATP is generated by mitochondria through the process of …
A single‐step synthesis of 5,6‐dihydropyrrolo[2,1‐a]isoquinolines and evaluation of their anti‐leukemic activity
H Park, SS Raikar, MJ Ahn, SH Kim… - Bulletin of the Korean …, 2024 - Wiley Online Library
While a pharmaceutically intriguing scaffold, 5, 6‐dihydropyrrolo [2, 1‐a] isoquinoline
(DHPIQ), has precedently been prepared from diverse tetrahydroisoquinolines (THIQs) …
(DHPIQ), has precedently been prepared from diverse tetrahydroisoquinolines (THIQs) …
The roles of mitochondrial cation channels under physiological conditions and in cancer
Bioenergetics has become central to our understanding of pathological mechanisms as well
as the development of new therapeutic strategies and as a tool for gauging disease …
as the development of new therapeutic strategies and as a tool for gauging disease …