Protein phosphatases act as key regulators of multiple important cellular processes and are
attractive therapeutic targets for various diseases. Although extensive effort has been …

Abstract Purpose of Review Juvenile-onset systemic lupus erythematosus ((j) SLE) is an
autoimmune/inflammatory disease that results in significant damage and disability. When …

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder that has a broad
spectrum of effects on the majority of organs, including the kidneys. Approximately 40–70 …

Systemic lupus erythematosus (SLE) is a chronic multi-organ debilitating autoimmune
disease, which mainly afflicts women in the reproductive years. A complex interaction of …

Inflammation is the common pathological basis of autoimmune diseases, metabolic
diseases, malignant tumors, and other major chronic diseases. Inflammation plays an …

Arctigenin (ATG) is a major component of Fructus Arctii, a traditional herbal remedy that
reduced proteinuria in diabetic patients. However, whether ATG specifically provides …

Abstract Protein Phosphatase 2A (PP2A) encompasses a large family of Ser/Thr
phosphatases, consisting of a catalytic C subunit and a structural A subunit that are, in most …

Glomerulonephritis is traditionally considered to result from the invasion of the kidney by
autoantibodies and immune complexes from the circulation or following their formation in …

T helper cells aid B cells with the production of antibodies and thus play a central role in
disease development of systemic lupus erythematosus (SLE). Numerous T helper cell …

Systemic lupus erythematosus (SLE) is a complicated autoimmune disorder characterized
by autoantibodies production, immune complex formation, and immune dysregulation …