Chronic pancreatitis (CP) is a continuing or relapsing inflammatory disease of the pancreas.
In approximately one-third of all cases, no aetiological factor can be found, and these …

Serine Peptidase Inhibitor Kazal Type 1 (SPINK1) is a secreted protein known as a protease
inhibitor of trypsin in the pancreas. However, emerging evidence shows its function in …

Progress made in identifying the genetic susceptibility underlying acute and chronic
pancreatitis has benefitted the clinicians in understanding the pathogenesis of the disease …

We previously identified a novel gene, reg (ie regenerating gene), in the screening of a rat
regenerating islet-derived cDNA library, and isolated its human cDNA homologue which …

From a subtracted cDNA library we have isolated a cDNA clone coding for a novel
transformation-sensitive protein which is expressed by human fibroblasts, but not by their …

Background: Mutations in the PRSS1 gene explain most occurrences of hereditary
pancreatitis (HP) but many HP families have no PRSS1 mutation. Recently, an association …

Pancreatitis is a global health care problem with varied aetiologies. Alcoholism is
responsible in the majority of patients while other causes, such as heredity, gallstones …

In the last 5 years, mutations in three genes, the cystic fibrosis transmembrane conductance
regulator (CFTR) gene, the cationic trypsinogen (PRSS1) gene, and the pancreatic secretory …

EDITOR—Ocular angioma (haemangioblastoma) is the most common presenting feature of
the multisystem familial cancer syndrome von Hippel-Lindau disease (VHL). 1 Recognition …

Background and aims: Mutations in the cationic trypsinogen (protease, serine, 1 (trypsin 1);
PRSS1) gene are causally associated with recurrent acute and chronic pancreatitis. We …