Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues

M Parola, M Pinzani - Molecular aspects of medicine, 2019 - Elsevier
The progression of chronic liver diseases (CLD), irrespective of etiology, involves chronic
parenchymal injury, persistent activation of inflammatory response as well as sustained …

Crosstalk between oxidative stress and inflammatory liver injury in the pathogenesis of alcoholic liver disease

YM Yang, YE Cho, S Hwang - International journal of molecular sciences, 2022 - mdpi.com
Alcoholic liver disease (ALD) is characterized by the injury, inflammation, and scarring in the
liver owing to excessive alcohol consumption. Currently, ALD is a leading cause for liver …

The role of intestinal permeability in gastrointestinal disorders and current methods of evaluation

T Vanuytsel, J Tack, R Farre - Frontiers in Nutrition, 2021 - frontiersin.org
An increased intestinal permeability has been described in various gastrointestinal and non-
gastrointestinal disorders. Nevertheless, the concept and definition of intestinal permeability …

Inflammatory pathways in alcoholic steatohepatitis

B Gao, MF Ahmad, LE Nagy, H Tsukamoto - Journal of hepatology, 2019 - Elsevier
Inflammatory processes are primary contributors to the development and progression of
alcoholic steatohepatitis (ASH), with severe alcoholic hepatitis characterised by non …

The gut-liver axis in health and disease: The role of gut microbiota-derived signals in liver injury and regeneration

Z Zheng, B Wang - Frontiers in immunology, 2021 - frontiersin.org
Diverse liver diseases undergo a similar pathophysiological process in which liver
regeneration follows a liver injury. Given the important role of the gut-liver axis in health and …

Gut–liver axis in alcoholic liver disease

G Szabo - Gastroenterology, 2015 - Elsevier
Alcoholic liver disease (ALD) has been among the leading causes of cirrhosis and liver-
related death worldwide for decades. Early discoveries in alcoholic liver disease identified …

[HTML][HTML] Pathogenesis of alcoholic liver disease: role of oxidative metabolism

E Ceni, T Mello, A Galli - World Journal of Gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
Alcohol consumption is a predominant etiological factor in the pathogenesis of chronic liver
diseases, resulting in fatty liver, alcoholic hepatitis, fibrosis/cirrhosis, and hepatocellular …

Alcoholic liver disease: pathogenesis and new therapeutic targets

B Gao, R Bataller - Gastroenterology, 2011 - Elsevier
Alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide and can
lead to fibrosis and cirrhosis. The latest surveillance report published by the National …

[HTML][HTML] Kupffer cells in the liver

LJ Dixon, M Barnes, H Tang, MT Pritchard… - Comprehensive …, 2013 - ncbi.nlm.nih.gov
Kupffer cells are a critical component of the mononuclear phagocytic system and are central
to both the hepatic and systemic response to pathogens. Kupffer cells are reemerging as …

Role of gut microbiota in chronic low‐grade inflammation as potential driver for atherosclerotic cardiovascular disease: a systematic review of human studies

ICL van den Munckhof, A Kurilshikov… - Obesity …, 2018 - Wiley Online Library
A hallmark of obesity is chronic low‐grade inflammation, which plays a major role in the
process of atherosclerotic cardiovascular disease (ACVD). Gut microbiota is one of the …