[PDF][PDF] Chikungunya vaccines: An update in 2023

P Roongaraya… - Asian Pacific Journal of …, 2023 - apjai-journal.org
A recent chikungunya outbreak affected 1.5 million cases in more than 60 countries. The
virus causes low mortality but moderate to severe morbidities such as high fever, myalgia …

Growth in chikungunya virus-related research in ASEAN and South Asian countries from 1967 to 2022 following disease emergence: a bibliometric and graphical …

F Sofyantoro, A Frediansyah, DS Priyono… - Globalization and …, 2023 - Springer
Abstract Background ASEAN (Association of Southeast Asian Nations) is composed of ten
Southeast Asian countries bound by socio-cultural ties that promote regional peace and …

Understanding the Biology and Immune Pathogenesis of Chikungunya Virus Infection for Diagnostic and Vaccine Development

MS Hakim, AT Aman - Viruses, 2022 - mdpi.com
Chikungunya virus, the causative agent of chikungunya fever, is generally characterized by
the sudden onset of symptoms, including fever, rash, myalgia, and headache. In some …

[HTML][HTML] Imidazonaphthyridine effects on Chikungunya virus replication: Antiviral activity by dependent and independent of interferon type 1 pathways

UEA Ruiz, IA Santos, VR Grosche, RS Fernandes… - Virus Research, 2023 - Elsevier
The Chikungunya virus (CHIKV) causes Chikungunya fever, a disease characterized by
symptoms such as arthralgia/polyarthralgia. Currently, there are no antivirals approved …

Distinct chikungunya virus polymerase palm subdomains contribute to viral protein accumulation and virion production

MF Martin, B Bonaventure, NE McCray… - PLoS …, 2024 - journals.plos.org
Alphaviruses encode an error-prone RNA-dependent RNA polymerase (RdRp), nsP4,
required for genome synthesis, yet how the RdRp functions in the complete alphavirus life …

[HTML][HTML] A structure-based drug design approach for the identification of antiviral compounds targeting the chikungunya virus RdRp protein

MH Ahmed, G Singh, M Castrosanto, A Hossain… - Chemical Physics …, 2024 - Elsevier
There are an estimated 3 million Chikungunya virus (CHIKV) infections per year, but no
vaccines or specific pharmaceutical treatments are available. RNA-dependent RNA …

Inhibition of early RNA replication in Chikungunya and Dengue virus by lycorine: In vitro and in silico studies

T Agrawal, G Siddqui, R Dahiya, A Patidar… - Biochemical and …, 2024 - Elsevier
Arboviruses such as chikungunya virus (CHIKV) and dengue virus (DENV) collectively afflict
millions of individuals worldwide particularly in endemic countries like India, leading to …

[HTML][HTML] Distinct chikungunya virus polymerase palm subdomains contribute to virus replication and virion assembly

MF Martin, B Bonaventure, NE McCray, OB Peersen… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Alphaviruses encode an error-prone RNA-dependent RNA polymerase (RdRp), nsP4,
required for genome synthesis, yet how the RdRp functions in the complete alphavirus life …

Understanding the resurgence of chikungunya virus during 2020− 2021 in Pune, India, based on genomic analyses: A seven year study

K Alagarasu, J Patil, S Jadhav… - Journal of Medical …, 2023 - Wiley Online Library
A surge in chikungunya was observed during 2020‐21 in Pune district of Maharashtra, India.
Whole genome sequencing and phylogenetic analysis of 21 samples/sequences revealed …

[PDF][PDF] In situ structural characterization of Chikungunya virus replication organelles by cryo-electron tomography

L Briant - researchgate.net
In situ structural characterization of Chikungunya virus replication organelles by cryo-electron
tomography Page 1 1 Présentée par Justine Girard Le 16 décembre 2022 Sous la direction …