The aging lung: Physiology, disease, and immunity
JL Schneider, JH Rowe, C Garcia-de-Alba, CF Kim… - Cell, 2021 - cell.com
The population is aging at a rate never seen before in human history. As the number of
elderly adults grows, it is imperative we expand our understanding of the underpinnings of …
elderly adults grows, it is imperative we expand our understanding of the underpinnings of …
The history and mystery of alveolar epithelial type II cells: focus on their physiologic and pathologic role in lung
Alveolar type II (ATII) cells are a key structure of the distal lung epithelium, where they exert
their innate immune response and serve as progenitors of alveolar type I (ATI) cells …
their innate immune response and serve as progenitors of alveolar type I (ATI) cells …
Lung adenocarcinoma promotion by air pollutants
A complete understanding of how exposure to environmental substances promotes cancer
formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two …
formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two …
The distribution of cellular turnover in the human body
We integrated ubiquity, mass and lifespan of all major cell types to achieve a comprehensive
quantitative description of cellular turnover. We found a total cellular mass turnover of 80±20 …
quantitative description of cellular turnover. We found a total cellular mass turnover of 80±20 …
The total number and mass of SARS-CoV-2 virions
Quantitatively describing the time course of the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection within an infected individual is important for …
coronavirus 2 (SARS-CoV-2) infection within an infected individual is important for …
The cellular and physiological basis for lung repair and regeneration: past, present, and future
The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …
Aging and lung disease
SJ Cho, HW Stout-Delgado - Annual review of physiology, 2020 - annualreviews.org
People worldwide are living longer, and it is estimated that by 2050, the proportion of the
world's population over 60 years of age will nearly double. Natural lung aging is associated …
world's population over 60 years of age will nearly double. Natural lung aging is associated …
The micromechanics of lung alveoli: structure and function of surfactant and tissue components
The mammalian lung´ s structural design is optimized to serve its main function: gas
exchange. It takes place in the alveolar region (parenchyma) where air and blood are …
exchange. It takes place in the alveolar region (parenchyma) where air and blood are …
p53 governs an AT1 differentiation programme in lung cancer suppression
Lung cancer is the leading cause of cancer deaths worldwide. Mutations in the tumour
suppressor gene TP53 occur in 50% of lung adenocarcinomas (LUADs) and are linked to …
suppressor gene TP53 occur in 50% of lung adenocarcinomas (LUADs) and are linked to …
AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19
SS Good, J Westover, KH Jung, XJ Zhou… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
The impact of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the
causative agent of COVID-19, is global and unprecedented. Although remdesivir has …
causative agent of COVID-19, is global and unprecedented. Although remdesivir has …