The past 50 years have seen a growing ageing population with an increasing prevalence of
type 2 diabetes mellitus (T2DM); now, nearly half of all individuals with diabetes mellitus are …

Both obesity and aging are associated with the development of metabolic diseases such as
type 2 diabetes and cardiovascular disease. Chronic low-grade inflammation of adipose …

Cardiometabolic diseases are an increasing global health burden. While socioeconomic,
environmental, behavioural, and genetic risk factors have been identified, a better …

Persistent hyper-inflammation is a distinguishing pathophysiological characteristic of chronic
wounds, and macrophage malfunction is considered as a major contributor thereof. In this …

Inflammaging, characterized by an increase in low‐grade chronic inflammation with age, is a
hallmark of aging and is strongly associated with various age‐related diseases, including …

Lines of evidence from several studies have shown that increases in life expectancy are now
accompanied by increased disability rate. The expanded lifespan of the aging population …

During aging, body adiposity increases with changes in the metabolism of lipids and their
metabolite levels. Considering lipid metabolism, excess adiposity with increased lipotoxicity …

The diagnosis of metabolic syndrome (MetS) focuses on the assessment of risk factors such
as insulin resistance, dyslipidemia, central adiposity and elevated blood pressure. Evidence …

Hematopoietic stem cell (HSC) aging was originally thought to be essentially an HSC-
autonomous process, which is the focus of another review in the same issue of …

Brown adipose tissue (BAT), a thermoregulatory organ known to promote energy
expenditure, has been extensively studied as a potential avenue to combat obesity …