Alzheimer's disease (AD) is a deadly, progressive, and irreversible brain condition that
impairs cognitive abilities. Globally, it affects 32.6 million individuals, and if no viable …

The discovery of acetylcholine and acetylcholinesterase provided the first insight into the
intricacies of chemical signal transduction and neuronal communication. Further elucidation …

The combination of the scaffolds of the cholinesterase inhibitor huprine Y and the
antioxidant capsaicin results in compounds with nanomolar potencies toward human …

This study was aimed at preparing and characterizing solid lipid nanoparticles (SLNs) of
donepezil (DPL) for delivery to brain via nasal route. SLNs were prepared by solvent …

The effect of fatty acids on the skin permeation of donepezil base (DPB) and its
hydrochloride salt (DPH) were studied in vitro using hairless mouse and human cadaver …

Forensic professionals, particularly medical examiners—often working through heavy
caseloads—require quick and easy access to reliable sources of information to help …

Background The aim of this study was to evaluate the effect of CYP2D6* 10 and APOE
polymorphisms on both steady-state plasma concentrations (Cp) and clinical response of …

A previously developed high performance liquid chromatography mass spectrometry (HPLC–
MS) procedure for the simultaneous determination of antidementia drugs, including …

Purpose This study aims to evaluate the influence of genetic polymorphisms of CYP2D6,
CYP3A5, ABCB1, and APOE genes and nongenetic factors on steady-state plasma …

The objective of this study was to characterize the mechanism that controls the transport of
donepezil into the brain. The apparent brain uptake clearance (CL app, br) was decreased …