Consensus guidelines for the use and interpretation of angiogenesis assays
The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …
important roles in growth and development, tissue and organ regeneration, as well as …
Animal models of human disease: zebrafish swim into view
GJ Lieschke, PD Currie - Nature Reviews Genetics, 2007 - nature.com
Despite the pre-eminence of the mouse in modelling human disease, several aspects of
murine biology limit its routine use in large-scale genetic and therapeutic screening. Many …
murine biology limit its routine use in large-scale genetic and therapeutic screening. Many …
Zebrafish as a model vertebrate for investigating chemical toxicity
AJ Hill, H Teraoka, W Heideman… - Toxicological …, 2005 - academic.oup.com
Zebrafish (Danio rerio) has been a prominent model vertebrate in a variety of biological
disciplines. Substantial information gathered from developmental and genetic research …
disciplines. Substantial information gathered from developmental and genetic research …
In vivo drug discovery in the zebrafish
LI Zon, RT Peterson - Nature reviews Drug discovery, 2005 - nature.com
The zebrafish has become a widely used model organism because of its fecundity, its
morphological and physiological similarity to mammals, the existence of many genomic tools …
morphological and physiological similarity to mammals, the existence of many genomic tools …
Spectrum of chemically induced mutations from a large-scale reverse-genetic screen in Arabidopsis
EA Greene, CA Codomo, NE Taylor, JG Henikoff… - Genetics, 2003 - academic.oup.com
Chemical mutagenesis has been the workhorse of traditional genetics, but it has not been
possible to determine underlying rates or distributions of mutations from phenotypic screens …
possible to determine underlying rates or distributions of mutations from phenotypic screens …
The use of zebrafish to understand immunity
For decades immunologists have relied heavily on the mouse model for their experimental
designs. With the realization of the important role innate immunity plays in orchestrating …
designs. With the realization of the important role innate immunity plays in orchestrating …
Real-time visualization of mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos
JM Davis, H Clay, JL Lewis, N Ghori, P Herbomel… - Immunity, 2002 - cell.com
Infection of vertebrate hosts with pathogenic Mycobacteria, the agents of tuberculosis,
produces granulomas, highly organized structures containing differentiated macrophages …
produces granulomas, highly organized structures containing differentiated macrophages …
tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors
S Berghmans, RD Murphey… - Proceedings of the …, 2005 - National Acad Sciences
TP53 is the most frequently mutated tumor suppressor gene in human cancer, with nearly
50% of all tumors exhibiting a loss-of-function mutation. To further elucidate the genetic …
50% of all tumors exhibiting a loss-of-function mutation. To further elucidate the genetic …
Zebrafish: model for the study of inflammation and the innate immune response to infectious diseases
B Novoa, A Figueras - Current topics in innate immunity II, 2012 - Springer
The zebrafish (Danio rerio) has been extensively used in biomedical research as a model to
study vertebrate development and hematopoiesis and recently, it has been adopted into …
study vertebrate development and hematopoiesis and recently, it has been adopted into …
[图书][B] The toxicology of fishes
RT Di Giulio, DE Hinton - 2008 - taylorfrancis.com
When looking for a book on fish toxicology, you might find one that discusses the
biochemical and molecular aspects, or one that focuses aquatic toxicology in general. You …
biochemical and molecular aspects, or one that focuses aquatic toxicology in general. You …