Mammalian cells harness autophagy to eliminate physiological byproducts of metabolism
and cope with microenvironmental perturbations. Moreover, autophagy connects cellular …

Autophagy comprises a growing range of cellular pathways, which occupy central roles in
response to energy deprivation, organelle turnover and proteostasis. Over the years …

Immunotherapies such as CAR-T cell transfer and antibody-targeted therapy have produced
promising clinical outcomes in patients with advanced and metastatic cancer that are …

Sorafenib is currently the only systemic agent approved for treatment of advanced
hepatocellular carcinoma (HCC). However, intrinsic and acquired resistance to sorafenib …

Macroautophagy delivers cytoplasmic constituents for lysosomal degradation. Since major
histocompatibility complex (MHC) class II molecules sample peptides after lysosomal …

CD4+ T cells are pivotal cells playing roles in the orchestration of humoral and cytotoxic
immune responses. It is known that CD4+ T cell proliferation relies on autophagy, but …

Invariant natural killer T (iNKT) cells are a distinct subset of innate-like lymphocytes bearing
an invariant T-cell receptor, through which they recognize lipid antigens presented by …

Autophagy is an evolutionarily conserved, multi-step lysosomal degradation process for the
clearance of damaged or superfluous proteins and organelles. Accumulating studies have …

Autophagy-related (ATG) gene products regulate macroautophagy, LC3-associated
phagocytosis (LAP) and LC3-dependent extracellular vesicle loading and secretion …

Autophagy is an essential cellular homeostasis pathway initiated by multiple stimuli ranging
from nutrient deprivation to viral infection, playing a key role in human health and disease. At …