Colorectal cancer (CRC) is the second most common newly diagnosed cancer and accounts
for the second highest number of cancer related deaths in Australia, the third worldwide and …

Molecular classification of colorectal cancer is evolving. As our understanding of colorectal
carcinogenesis improves, we are incorporating new knowledge into the classification …

Background: The CpG island methylator phenotype (CIMP), characterised by widespread
promoter methylation, is associated with microsatellite instability (MSI) and BRAF mutation in …

Colorectal cancer (CRC) is one of the most frequent tumor entities worldwide with only
limited therapeutic options. CRC is not only a genetic disease with several mutations in …

The genetics of schizophrenia has been approached utilizing a variety of methods. One
emerging strategy is the use of endophenotypes in order to understand and identify the …

Aim Recent evidence suggests that several dietary polyphenols may exert their
chemopreventive effect through epigenetic modifications. Curcumin is one of the most …

Colorectal cancer (CRC) has predominantly been considered a genetic disease,
characterized by sequential accumulation of genetic alterations. Growing evidence indicates …

Each differentiated cell type has its own epigenetic signature, which reflects its genotype,
developmental history, and environmental influences, and is ultimately reflected in the …

Since the MOSAIC study, oxaliplatin-based adjuvant chemotherapy has been the standard
treatment of stage III colon cancer. Combination therapy with fluoropyrimidines and …

Epigenetic regulation of gene expression is, at least in part, mediated by histone
modifications. PTMs of histones change chromatin structure and regulate gene transcription …