Reactive glia inflammatory signaling pathways and epilepsy

P Sanz, MA Garcia-Gimeno - International journal of molecular sciences, 2020 - mdpi.com
Neuroinflammation and epilepsy are interconnected. Brain inflammation promotes neuronal
hyper-excitability and seizures, and dysregulation in the glia immune-inflammatory function …

New mechanisms of ginseng saponin-mediated anti-inflammatory action via targeting canonical inflammasome signaling pathways

YS Yi - Journal of Ethnopharmacology, 2021 - Elsevier
Ethnopharmacological relevance Ginseng is an ethnopharmacological herbal plant in Asian
countries, particularly in Korea, China, and Japan. Ginseng saponins, including …

Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-κB/NLRP3-mediated epithelial–mesenchymal transition and inflammation

L Peng, L Wen, QF Shi, F Gao, B Huang, J Meng… - Cell death & …, 2020 - nature.com
Idiopathic pulmonary fibrosis (IPF) is featured with inflammation and extensive lung
remodeling caused by overloaded deposition of extracellular matrix. Scutellarin is the major …

Epigallocatechin‐3‐gallate attenuates microglial inflammation and neurotoxicity by suppressing the activation of canonical and noncanonical inflammasome via TLR4 …

X Zhong, M Liu, W Yao, K Du, M He… - Molecular nutrition & …, 2019 - Wiley Online Library
Scope In this study, it has been investigated whether the neuroprotective efficacy of
epigallocatechin‐3‐gallate (EGCG) is mediated by inhibition of canonical and noncanonical …

Caspase-4/11–mediated pulmonary artery endothelial cell pyroptosis contributes to pulmonary arterial hypertension

Y Wu, B Pan, Z Zhang, X Li, Y Leng, Y Ji, K Sun… - …, 2022 - Am Heart Assoc
Background: Endothelial dysfunction enhances vascular inflammation, which initiates
pulmonary arterial hypertension (PAH) pathogenesis, further induces vascular remodeling …

[HTML][HTML] Potential benefits of ginseng against COVID-19 by targeting inflammasomes

YS Yi - Journal of Ginseng Research, 2022 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogenic virus that
causes coronavirus disease 2019 (COVID-19), with major symptoms including hyper …

The Antitriple Negative Breast cancer Efficacy of Spatholobus suberectus Dunn on ROS‐Induced Noncanonical Inflammasome Pyroptotic Pathway

F Zhang, Q Liu, K Ganesan, Z Kewu… - Oxidative Medicine …, 2021 - Wiley Online Library
Breast cancer (BCa) is the leading cause of women's death worldwide; among them, triple‐
negative breast cancer (TNBC) is one of the most troublesome subtypes with easy …

Inhibition of NLRP3 inflammasome: a prospective target for the treatment of ischemic stroke

YS Feng, ZX Tan, MM Wang, Y Xing, F Dong… - Frontiers in Cellular …, 2020 - frontiersin.org
Stroke is one of the major devastating diseases with no effective medical therapeutics.
Because of the high rate of disability and mortality among stroke patients, new treatments …

Anti-inflammatory role of Artemisia argyi methanol extract by targeting the caspase-11 non-canonical inflammasome in macrophages

YB Kim, HJ Cho, YS Yi - Journal of Ethnopharmacology, 2023 - Elsevier
Ethnopharmacological relevance Artemisia argyi possesses pharmacological activities
against various immunopathological conditions associated with inflammation. Aim of the …

Microglial NLRP3 inflammasome activation in multiple sclerosis

M Olcum, B Tastan, C Kiser, S Genc, K Genc - Advances in protein …, 2020 - Elsevier
Multiple sclerosis (MS) is a chronic, autoimmune and neuroinflammatory disease of the
central nervous system (CNS) mediated by autoreactive T cells directed against myelin …