iNKT cells, CD1d dependent natural killer T cells are a unique population of T cells. The
capacity of iNKT cells to produce regulatory cytokines first provided an indication of their …

Type 1 diabetes mellitus (T1DM) results from death of insulin-secreting β cells mediated by
self-immune cells, and the consequent inability of the body to maintain insulin levels for …

Type 1 diabetes mellitus (T1D) and multiple sclerosis (MS) are organ-specific autoimmune
diseases leading to an attack of auto-aggressive lymphocytes against the pancreatic β-cells …

Type 1 diabetes is caused by autoreactive T cells that destroy pancreatic beta cells. Animal
models suggested that a CD4+ CD25+ population has a regulatory function capable of …

Objective (s): Regulatory T cells, including CD4+ CD25+ Fox3+ and CD8+ CD28-cells play
an important role in regulating the balance between immunity and tolerance. Since multiple …

Type 1 diabetes is increasing dramatically in incidence in the developed world. While there
may be several reasons for this, improved sanitation and public health measures have …

Reported alterations in Treg cells from type 1 diabetes (T1D) patients led us to a revision of
their phenotypical features compared with controls. A fine cytometric analysis was designed …

Abstract Abnormalities in CD4+ CD25+ regulatory T cells (Treg) may contribute to type 1
diabetes (T1D) development. First‐degree relatives of T1D patients are at increased risk …

Diabetes type 1 is a chronic autoimmune disease in which insulin‐producing cells are
gradually destroyed by autoreactive T cells. Human regulatory cells play important role in …

Abstract Type 1 diabetes (T1D) has a strong genetic component and the major locus lies in
the HLA DQB1 region. We found earlier an increased apoptosis with decreased viability and …