MicroRNAs (miRNAs), which are noncoding RNAs that regulate gene expression, are
involved in tumor metastasis. In this study, we describe the down-regulation and function of …

MicroRNAs are small non-protein-coding RNAs which repress gene expression, through
base pair matching with messenger RNA (mRNA). A single microRNA is capable of …

The antiapoptotic protein Bcl‐2 is overexpressed in human cancers, and confers resistance
to antitumor agents in cancer cells. Bcl‐2 is negatively regulated by the tumor suppressor …

Mesenchymal stem cells (MSCs) are attractive candidates for cell therapy and regenerative
medicine because of their potential for proliferation and multilineage differentiation. MSCs …

The p53 tumor suppressor pathway is impaired in more than 90% of cervical cancers and
cancer‐derived cell lines as a result of infection by human papillomavirus (HPV). The HPV …

Gemcitabine (GEM), a new cytotoxic agent, was shown to be effective against uveal
melanoma (UM) which is noted for its resistance to chemotherapy. In this study, we found the …

RHOXF1 has been shown to be expressed in embryonic stem cells, adult germline stem
cells and some cancer lines. It has been proposed as a candidate gene to encode …

Abstract Vitamin K2 (VK2) exerts cell growth inhibitory effects in various human cancer cells
such as SMMC-7721 hepatocellular carcinoma (HCC) cells. BCL-2 is an antiapoptotic …

This teaching monograph on systems approaches to cancer research and clinical
applications provides a unique synthesis, by world-class scientists and doctors, of …

Gene silencing by RNA interference has become a very promising technique in the fields of
biomedical and life sciences during the past few years. In this approach, small interfering …