Excess body weight is frequently associated with low-grade inflammation. Evidence
indicates a relationship between obesity and cancer, as well as with other diseases, such as …

Protein neddylation is a post-translational modification, and its best recognized substrates
are cullin family proteins, which are the core component of Cullin-RING ligases (CRLs) …

Glioblastoma multiforme (GBM) is the most common type of primary brain tumor in adults.
GBM is characterized by a high degree of malignancy and aggressiveness, as well as high …

Glioma is one of the most common malignant tumors of the central nervous system, and its
prognosis is extremely poor. Aberrant methylation of lncRNA promoter region is significantly …

Cancer is a challenging issue for human health. One of the key methods to address this
issue is by comprehending the molecular causes of tumors and creating medications that …

Ubiquitination is a modification of proteins that has a powerful impact on protein function
along with other cellular functions. This reaction is regulated through major enzymes …

RNF7 has been reported to play critical roles in various cancers. However, the underlying
mechanisms of RNF7 in glioma development remain largely unknown. Herein, the …

Glioma is a prevalent malignant tumour characterized by hypoxia as a pivotal factor in its
progression. This study aims to investigate the impact of the most severely hypoxic cell …

Hypoxic pulmonary hypertension (HPH) lacks effective pharmacologic treatments.
Microarray-based gene expression indicates the crucial role of Cullin 5 (Cul 5) in HPH. This …

The ubiquitin proteasome system (UPS) serves as the major posttranslational modification
system for the maintenance of protein homeostasis. The ubiquitin ligases (E3s) are …