We discuss the upstream regulators of myogenesis that lead to the activation of myogenic
determination genes and subsequent differentiation, focusing on the mouse model. Key …

During embryogenesis, skeletal muscle forms in the vertebrate limb from progenitor cells
originating in the somites. These cells delaminate from the hypaxial edge of the dorsal part …

The basic helix-loop-helix myogenic regulatory factors MyoD, Myf5, myogenin and MRF4
have critical roles in skeletal muscle development. Together with the Mef2 proteins and E …

Pax genes play key roles in the formation of tissues and organs during embryogenesis.
Pax3 and Pax7 mark myogenic progenitor cells and regulate their behavior and their entry …

Urinary tract malformations constitute the most frequent cause of chronic renal failure in the
first two decades of life. Branchio-otic (BO) syndrome is an autosomal dominant …

Continuing research on the onset of skeletal myogenesis in the somite is providing new
insights into the behaviour of early myogenic progenitor cells and how signalling molecules …

Patients presenting with metastatic rhabdomyosarcoma (RMS), the most common soft-tissue
sarcoma in children, have a very poor clinical prognosis. This is due, in large part, to our …

Muscle fibres have different properties with respect to force, contraction speed, endurance,
oxidative/glycolytic capacity etc. Although adult muscle fibres are normally post‐mitotic with …

Seasonal synchronization based on day length (photoperiod) allows organisms to anticipate
environmental change. Photoperiodic decoding relies on circadian clocks, but the …

Skeletal muscle has an intrinsic capacity for regeneration following injury or exercise. The
presence of adult stem cells in various tissues with myogenic potential provides new …